Highly Efficient "Grafting onto" a Polypeptide Backbone Using Click Chemistry

被引：213

作者：

Engler, Amanda C. ^{[1
]}

Lee, Hyung-il ^{[1
,2
]}

Hammond, Paula T. ^{[1
]}

机构：

[1] MIT, Dept Chem Engn, Cambridge, MA 02139 USA

[2] Univ Ulsan, Dept Chem, Ulsan 680749, South Korea

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2009年 / 48卷 / 49期

关键词：

alkynes; azides; click chemistry; grafting; polypeptides; RING-OPENING POLYMERIZATION; ACID N-CARBOXYANHYDRIDES; ALIPHATIC POLYESTERS; MOLECULAR BRUSHES; BLOCK-COPOLYMERS; FUNCTIONALIZATION; DRUG; ATRP; CONFORMATION; SPECTROSCOPY;

D O I：

10.1002/anie.200904070

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical figure equation) Clicked" into place: Densely grafted poly(γ-propargyl-L-glutamate)-g-poly(ethylene glycol) polypeptides have been synthesized by combining ring-opening polymerization of N-carboxyanhydrides with click chemistry. Various lengths of poly(ethylene glycol) (PEG) side chains (750 g mol-1 to 5000 g mol-1) were attached to a rigid α-helical poly(γ-propargyl-L-glutamate); extremely high grafting efficiencies of over 96% were achieved. © 2009 Wiley-VCH Verlag GmbH & Co. KGaA."

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页码：9334 / 9338

页数：5

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