Transition Metal-Catalyzed Direct Arylation of Substrates with Activated sp3-Hybridized C-H Bonds and Some of Their Synthetic Equivalents with Aryl Halides and Pseudohalides

A study was conducted to demonstrate transition metal-catalyzed direct arylation of substrates with activated sp3-hybridized C-H bonds and some of their synthetic equivalents with aryl halides and pseudohalides. The study also focused on the catalyst system and experimental conditions used for the regioselective synthesis of α-arylated compounds through transition metal-catalyzed arylation of synthetic equivalents of carbonyl compounds. The synthetic equivalents of carbonyl compounds included silyl enol ethers and enol ethers of ketones and silyl ketone acetals using aryl halides or pseudohalides as electrophiles. The investigations also highlighted the utility of these experimentally simple reactions that proceeded without requiring preparation of stoichiometric amounts of organometallics.