The role of NK cell recognition of nectin and nectin-like proteins in tumor immunosurveillance

被引：130

作者：

Fuchs, Anja ^{[1
]}

Colonna, Marco ^{[1
]}

机构：

[1] Washington Univ, Sch Med, Dept Pathol & Immunol, St Louis, MO 63130 USA

来源：

SEMINARS IN CANCER BIOLOGY | 2006年 / 16卷 / 05期

关键词：

D O I：

10.1016/j.semcancer.2006.07.002

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Natural killer (NK) cells have important functions in the innate immunity to tumors. Recognition of tumor cells by NK cells is mediated by the interaction of activating and inhibitory NK cell receptors with ligands expressed on the tumor target. In addition, NK cell-target cell interactions require the engagement of adhesion molecules that stabilize the cell-cell conjugate. Recently, several novel NK cell receptors have been reported to regulate NK cell adhesion and activation through interaction with ligands of the nectin and nectin-like (Necl) family of adhesion molecules. We here review current knowledge on these receptors, CD226, CD96 and CRTAM, and their role in tumor immunosurveillance. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：359 / 366

页数：8

共 54 条

[1] Heterotypic interaction of CRTAM with Necl2 induces cell adhesion on activated NK cells and CD8+ T cells [J].

Arase, N ;

Takeuchi, A ;

Unno, M ;

Hirano, S ;

Yokosuka, T ;

Arase, H ;

Saito, T .

INTERNATIONAL IMMUNOLOGY, 2005, 17 (09) :1227-1237

[2] Identification of secreted CD155 isoforms [J].

Baury, W ;

Masson, D ;

McDermott, BM ;

Jarry, A ;

Blottière, HM ;

Blanchardie, P ;

Laboisse, CL ;

Lustenberger, P ;

Racaniello, VR ;

Denis, MG .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2003, 309 (01) :175-182

[3] SynCAM, a synaptic adhesion molecule that drives synapse assembly [J].

Biederer, T ;

Sara, Y ;

Mozhayeva, M ;

Atasoy, D ;

Liu, XR ;

Kavalali, ET ;

Südhof, TC .

SCIENCE, 2002, 297 (5586) :1525-1531

[4] The tumor suppressor TSLC1/NECL-2 triggers NK-cell and CD8+ T-cell responses through the ceff-surface receptor CRTAM [J].

Boles, KS ;

Barchet, W ;

Diacovo, T ;

Cella, M ;

Colonna, M .

BLOOD, 2005, 106 (03) :779-786

[5] Identification of PVR (CD155) and nectin-2 (CD112) as cell surface ligands for the human DNAM-1 (CD226) activating molecule [J].

Bottino, C ;

Castriconi, R ;

Pende, D ;

Rivera, P ;

Nanni, M ;

Carnemolla, B ;

Cantoni, C ;

Grassi, J ;

Marcenaro, S ;

Reymond, N ;

Vitale, M ;

Moretta, L ;

Lopez, M ;

Moretta, A .

JOURNAL OF EXPERIMENTAL MEDICINE, 2003, 198 (04) :557-567

[6] TLISA1, A HUMAN T-LINEAGE SPECIFIC ACTIVATION ANTIGEN INVOLVED IN THE DIFFERENTIATION OF CYTO-TOXIC LYMPHOCYTES-T AND ANOMALOUS KILLER CELLS FROM THEIR PRECURSORS [J].

BURNS, GF ;

TRIGLIA, T ;

WERKMEISTER, JA ;

BEGLEY, CG ;

BOYD, AW .

JOURNAL OF EXPERIMENTAL MEDICINE, 1985, 161 (05) :1063-1078

[7] Natural killer cell-mediated killing of freshly isolated neuroblastoma cells: Critical role of DNAX accessory molecule-1-poliovirus receptor interaction [J].

Castriconi, R ;

Dondero, A ;

Corrias, MV ;

Lanino, E ;

Pende, D ;

Moretta, L ;

Bottino, C ;

Moretta, A .

CANCER RESEARCH, 2004, 64 (24) :9180-9184

[8] CD226 is specifically expressed on the surface of Th1 cells and regulates their expansion and effector functions [J].

Dardalhon, V ;

Schubart, AS ;

Reddy, J ;

Meyers, JH ;

Monney, L ;

Sabatos, CA ;

Ahuja, R ;

Nguyen, K ;

Freeman, GJ ;

Greenfield, EA ;

Sobel, RA ;

Kuchroo, VK .

JOURNAL OF IMMUNOLOGY, 2005, 175 (03) :1558-1565

[9] RETRACTED: CD226 expression deficiency causes high sensitivity to apoptosis in NKT cells from patients with systemic lupus erythematosus (Retracted Article) [J].

Deng, T ;

Liu, SW ;

Wu, Q ;

Liu, Y ;

Ju, W ;

Liu, JY ;

Gong, FL ;

Jin, BQ ;

Tan, JQ .

JOURNAL OF IMMUNOLOGY, 2005, 174 (03) :1281-1290

[10] The three Es of cancer immunoediting [J].

Dunn, GP ;

Old, LJ ;

Schreiber, RD .

ANNUAL REVIEW OF IMMUNOLOGY, 2004, 22 :329-360

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