Implantable closed-loop glucose-sensing and insulin delivery: the future for insulin pump therapy

被引：89

作者：

Renard, E ^{[1
]}

机构：

[1] Lapeyronie Hosp, Dept Endocrinol, F-34295 Montpellier 5, France

来源：

CURRENT OPINION IN PHARMACOLOGY | 2002年 / 2卷 / 06期

关键词：

D O I：

10.1016/S1471-4892(02)00216-3

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Although subcutaneous insulin infusion from portable pumps is the current optimal therapy for type 1 diabetic patients, implantable pumps using the intraperitoneal route allow increased blood glucose stability and lowered incidence of severe hypoglycemia. Subcutaneously implanted enzymatic glucose sensors provide continuous interstitial glucose monitoring, but this may differ from the real-time blood glucose levels. Preliminary investigations of intravascular enzymatic sensors demonstrate their clinical acceptability and accuracy and the possibility of developing closed-loop insulin delivery by combination with implantable pumps.

引用

页码：708 / 716

页数：9

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