Genome-Wide Transcriptional Profiling of the Response of Staphylococcus aureus to Cryptotanshinone

被引：23

作者：

Feng, Haihua ^{[1
]}

Xiang, Hua ^{[1
]}

Zhang, Jiyu ^{[2
]}

Liu, Guowen ^{[1
]}

Guo, Na ^{[1
]}

Wang, Xuelin ^{[1
]}

Wu, Xiuping ^{[1
]}

Deng, Xuming ^{[1
]}

Yu, Lu ^{[1
]}

机构：

[1] Jilin Univ, Inst Zoonosis, Coll Anim Sci & Vet Med, Key Lab Zoonosis,Minist Educ, Changchun 130062, Peoples R China

[2] Chinese Acad Agr Sci, Lanzhou Inst Anim Sci & Vet Pharmaceut Sci, Lanzhou 730050, Peoples R China

来源：

JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY | 2009年

关键词：

GENE-EXPRESSION; ESCHERICHIA-COLI; RESISTANCE; BACTERIAL; BIOSYNTHESIS; SUPEROXIDE; PREVENTION; CATALASE; PATHWAY; SYSTEM;

D O I：

10.1155/2009/617509

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Staphylococcus aureus (S. aureus) strains with multiple antibiotic resistances are increasingly widespread, and new agents are required for the treatment of S. aureus. Cryptotanshinone (CT), a major tanshinone of medicinal plant Salvia miltiorrhiza Bunge, demonstrated effective in vitro antibacterial activity against all 21 S. aureus strains tested in this experiment. Affymetrix GeneChips were utilized to determine the global transcriptional response of S. aureus ATCC 25923 to treatment with subinhibitory concentrations of CT. Transcriptome profiling indicated that the antibacterial action of CT may be associated with its action as active oxygen radical generator; S. aureus undergoes an oxygen-limiting state upon exposure to CT. Copyright (C) 2009 Haihua Feng et al.

引用

页数：8

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