Systems biology asks new questions about sex differences

被引：26

作者：

Arnold, Arthur P. ^{[1
]}

van Nas, Atila ^{[2
]}

Lusis, Aldons J. ^{[2
,3
,4
]}

机构：

[1] Univ Calif Los Angeles, Dept Physiol Sci, Los Angeles, CA 90095 USA

[2] Univ Calif Los Angeles, Dept Human Genet, Los Angeles, CA USA

[3] Univ Calif Los Angeles, Dept Microbiol Immunol & Mol Genet, Los Angeles, CA USA

[4] Univ Calif Los Angeles, Dept Med, Los Angeles, CA 90024 USA

来源：

TRENDS IN ENDOCRINOLOGY AND METABOLISM | 2009年 / 20卷 / 10期

基金：

美国国家卫生研究院;

关键词：

BIASED GENE-EXPRESSION; CHROMOSOMES; NETWORKS; BRAIN; DROSOPHILA; GENDER; MICE; FAT;

D O I：

10.1016/j.tem.2009.06.007

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Females and males differ in physiology and in the incidence and progression of diseases. The sex-biased proximate factors causing sex differences in phenotype include direct effects of gonadal hormones and of genes represented unequally in the genome because of their X- or Y-linkage. Novel systems approaches have begun to assess the magnitude and character of sex differences in organization of gene networks on a genome-wide scale. These studies identify functionally related modules of genes that are coexpressed differently in males and females, and sites in the genome that regulate gene networks in a sex-specific manner. Measurement of the aggregate behavior of genes uncovers novel sex differences that can be related more effectively to susceptibility to disease.

引用

页码：471 / 476

页数：6

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