Delivery of recombinant bone morphogenetic proteins for bone regeneration and repair. Part A: Current challenges in BMP delivery

被引：186

作者：

Haidar, Ziyad S. ^{[1
,2
,3
,4
,5
]}

Hamdy, Reggie C. ^{[1
,3
,4
]}

Tabrizian, Maryam ^{[1
,2
,5
]}

机构：

[1] McGill Univ, Ctr Biorecognit & Biosensors, Montreal, PQ H3A 2B4, Canada

[2] McGill Univ, Dept Biomed Engn, Fac Med, Montreal, PQ H3A 2B4, Canada

[3] McGill Univ, Montreal Childrens Hosp, Shriners Hosp Children, Montreal, PQ H3A 1A6, Canada

[4] McGill Univ, Montreal Childrens Hosp, Div Orthopaed, Montreal, PQ H3A 1A6, Canada

[5] McGill Univ, Fac Dent, Montreal, PQ H3A 1A4, Canada

来源：

BIOTECHNOLOGY LETTERS | 2009年 / 31卷 / 12期

基金：

加拿大健康研究院;

关键词：

Bone morphogenetic proteins; Bone regeneration; Bone repair; Craniofacial surgery; Delivery systems; Orthopaedics; RELEASE KINETICS; DISTRACTION OSTEOGENESIS; CLINICAL-APPLICATIONS; GROWTH-FACTORS; EFFICACY; COLLAGEN; OP-1; INJECTION; SCAFFOLDS; CHITOSAN;

D O I：

10.1007/s10529-009-0099-x

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Recombinant human bone morphogenetic proteins (rhBMPs) have been extensively investigated for developing therapeutic strategies aimed at the restoration and treatment of orthopaedic as well as craniofacial conditions. In this first part of the review, we discuss the rationale for the necessary use of carrier systems to deliver rhBMP-2 and rhBMP-7 to sites of bone tissue regeneration and repair. General requirements for growth factor delivery systems emphasizing the distinction between localized and release-controlled delivery strategies are presented highlighting the current limitations in the development of an effective rhBMP delivery system applicable in clinical bone tissue engineering.

引用

页码：1817 / 1824

页数：8

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