Bone morphogenetic proteins in tissue engineering: the road from the laboratory to the clinic, part I (basic concepts)

被引：256

作者：

Bessa, P. C. ^{[1
,2
,3
]}

Casal, M. ^{[3
]}

Reis, R. L. ^{[1
,2
]}

机构：

[1] Univ Minho, Res Grp 3Bs, Dept Polymer Engn, P-4710057 Braga, Portugal

[2] IBB, PT Govt Associated Lab, P-4710057 Braga, Portugal

[3] Univ Minho, Mol & Environm Biol Ctr CBMA, Dept Biol, P-4710057 Braga, Portugal

来源：

JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE | 2008年 / 2卷 / 01期

关键词：

bone morphogenetic proteins; bone morphogenetic protein receptor; Smad signalling; BMP signalling; recombinant BMP; tissue engineering;

D O I：

10.1002/term.63

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Discovered in 1965, bone morphogenetic proteins (BMPs) are a group of cytokines from the transforming growth factor-beta (TGF beta) superfamily with significant roles in bone and cartilage formation. BMPs are used as powerful osteoinductive components of diverse tissue-engineering products for the healing of bone. Several BMPs with different physiological roles have been identified in humans. The purpose of this review is to cover the biological function of the main members of BMP family, the latest research on BMPs signalling pathways and advances in the production of recombinant BMPs for tissue engineering purposes. Copyright (c) 2008 John Wiley & Sons, Ltd.

引用

页码：1 / 13

页数：13

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