First application of tunable alkyl or aryl sulfinamides to the stereoselective synthesis of a chiral amine:: Asymmetric synthesis of (R)-didesmethylsibutramine ((R)-DDMS) using (R)-triethylmethylsulfinamide ((R)-TESA)

被引：37

作者：

Han, ZX ^{[1
]}

Krishnamurthy, D ^{[1
]}

Pflum, D ^{[1
]}

Grover, P ^{[1
]}

Wald, SA ^{[1
]}

Senanayake, CH ^{[1
]}

机构：

[1] Sepracor Inc, Chem Proc Res & Dev, Marlborough, MA 01752 USA

来源：

ORGANIC LETTERS | 2002年 / 4卷 / 23期

关键词：

D O I：

10.1021/ol026699q

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] highly diastereoselective addition of i-BuLi to a triethylmethylsulfinamide derived aldimine was used as the key step in the first asymmetric synthesis of (R)-didesmethylsibutramine, a metabolite of sibutramine for the potential treatment of CNS disorders.

引用

页码：4025 / 4028

页数：4

共 27 条

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