Role of operculoinsular cortices in human pain processing:: Converging evidence from PET, fMRI, dipole modeling, and intracerebral recordings of evoked potentials

被引:157
作者
Peyron, R
Frot, M
Schneider, F
Garcia-Larrea, L
Mertens, P
Barral, FG
Sindou, M
Laurent, B
Mauguière, F
机构
[1] CHU St Etienne, Dept Neurol, Bellevue Hosp, F-42055 St Etienne 02, France
[2] CHU St Etienne, Ctr Douleur, Bellevue Hosp, F-42055 St Etienne 02, France
关键词
pain; insula; SII; PET; fMRI; laser-evoked potentials; human brain; intracerebral recordings; dipole modeling;
D O I
10.1006/nimg.2002.1315
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Insular and SII cortices have been consistently shown by PET, fMRI, EPs, and MEG techniques to be activated bilaterally by a nociceptive stimulation. The aim of the present study was to refer to, and to compare within a common stereotactic space, the nociceptive responses obtained in humans by (i) PET, (ii) fMRI, (iii) dipole modeling of scalp LEPs, and (iv) intracerebral recordings of LEPs. PET, fMRI, and scalp LEPs were obtained from normal subjects during thermal pain. Operculoinsular LEPs were obtained from 13 patients using deep brain electrodes implanted for presurgical evaluation of drug-resistant epilepsy. Whatever the technique, we obtained responses which were located bilaterally in the insular and SII cortices. In electrophysiological responses (LEPs) the SII insular contribution peaked between 150 and 250 ms poststimulus and corresponded to the earliest portions of the whole cerebral response. Group analysis of PET and fMRI data showed highly consistent responses contralateral to stimulation. On single-subject analysis, LEPs and fMRI activations were concentrated in relatively restricted volumes even though spatial sampling was quite different for both techniques. Despite our multimodal approach, however, it was not possible to separate insular from SII activities. Individual variations in the anatomy and function of SII and insular cortices may explain this limitation. This multimodal study provides, however, cross-validated spatial and temporal information on the pain-related processes occurring in the operculoinsular region, which thus appears as a major site for the early cortical pain encoding in the human brain. (C) 2002 Elsevier Science (USA).
引用
收藏
页码:1336 / 1346
页数:11
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