An autosomal genomic scan for loci linked to plasma leptin concentration in Pima Indians

被引：29

作者：

Walder, K ^{[1
]}

Hanson, RL ^{[1
]}

Kobes, S ^{[1
]}

Knowler, WC ^{[1
]}

Ravussin, E ^{[1
]}

机构：

[1] NIDDKD, Diabet & Arthritis Epidemiol Sect, NIH, Phoenix Epidemiol & Clin Res Branch, Phoenix, AZ 85014 USA

来源：

INTERNATIONAL JOURNAL OF OBESITY | 2000年 / 24卷 / 05期

关键词：

genetics; leptin; linkage analysis; obesity;

D O I：

10.1038/sj.ijo.0801197

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

OBJECTIVE: To identify chromosomal regions linked to plasma leptin concentrations. DESIGN: Autosomal genome-wide scan, including 516 microsatellite markers. Sib-pair (Haseman-Elston) and variance components methods were used to assess genetic linkage. SUBJECTS: 770 Pima Indians comprising 239 nuclear families (for a total of 1199 sibling-pairs). MEASUREMENTS: Plasma leptin concentrations and body mass index (BMI), adjusted for age and sex. RESULTS: The strongest evidence for linkage with plasma leptin concentration was on chromosome 6p logarithm of odds (LOD) = 2.1 by variance components analysis. There was no evidence for linkage to BMI in this region. Additional regions with marginal evidence for linkage to plasma leptin concentration (LOD greater than or equal to 1.0) were detected on chromosomes 3, 11, 13, 15 and 16. CONCLUSIONS: The results suggest that a locus on chromosome 6p influences plasma leptin concentrations. Replication studies are needed to exclude the possibility that linkage has been falsely detected.

引用

页码：559 / 565

页数：7

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