2′-deoxyguanosine (DG) oxidation and strand-break formation in DNA by the radicals released in the photolysis of N-tert-butoxy-2-pyridone.: Are tert-butoxyl or methyl radicals responsible for the photooxidative damage in aqueous media?

被引：14

作者：

Adam, W

Marquardt, S

Kemmer, D

Saha-Möller, CR

Schreier, P

机构：

[1] Univ Wurzburg, Inst Organ Chem, D-97074 Wurzburg, Germany

[2] Univ Wurzburg, Inst Lebensmittelchem, D-97074 Wurzburg, Germany

来源：

ORGANIC LETTERS | 2002年 / 4卷 / 02期

关键词：

D O I：

10.1021/ol016955j

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] The photolysis of pyridone 3b (photo-Fenton reagent) in benzene releases tent-butoxyl radicals, which have been trapped by DMPO and EPR-spectrally identified. In, aqueous solution, however, the fragmentation of the tent-butoxyl into methyl radicals prevails and the former radicals are of no direct consequence in the photooxidation of 2'-deoxyguanosine (dG) and pBR 322 DNA. The photooxidative damage of nucleic acids is caused by the oxyl radical species generated from the methyl radicals with oxygen.

引用

页码：225 / 228

页数：4

共 22 条

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