A reversible colorimetric and fluorescent polydiacetylene vesicle sensor platform

被引：47

作者：

Yuan, Zhongzhe ^{[1
]}

Hanks, Timothy W. ^{[1
]}

机构：

[1] Furman Univ, Dept Chem, Greenville, SC 29613 USA

来源：

POLYMER | 2008年 / 49卷 / 23期

基金：

美国国家科学基金会;

关键词：

Polydiacetylene; Liposome; Biosensor;

D O I：

10.1016/j.polymer.2008.09.008

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

A multi-functional liposome has been developed that demonstrates reversible changes in color and fluorescence intensity in response to changes in pH. Addition of a pendant tryptophan moiety gives the assembly the ability to detect Escherichia coli. The sensor platform is made from a polymerized vesicular assembly of hydrazide-terminated diacetylene lipids and a BO558 fluorescent dye. The polymer backbone is responsible for the color change, while the organization induced by hydrogen bonding of the terminal hydrazide groups permits the reversibility of the color change. Fluorescence quenching is due to internal rearrangement of the liposome and occurs in both polymerized and unpolymerized structures. (C) 2008 Elsevier Ltd. All rights reserved.

引用

收藏

页码：5023 / 5026

页数：4

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