AMPK: A key sensor of fuel and energy status in skeletal muscle

被引：405

作者：

Hardie, DG ^{[1
]}

Sakamoto, K

机构：

[1] Univ Dundee, Div Mol Physiol, Dundee, Scotland

[2] Univ Dundee, MRC, Prot Phosphorylat Unit, Dundee, Scotland

来源：

PHYSIOLOGY | 2006年 / 21卷

基金：

英国医学研究理事会; 英国惠康基金;

关键词：

D O I：

10.1152/physiol.00044.2005

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Contraction induces marked metabolic changes in muscle, and the AMP-activated protein kinase (AMPK) is a good candidate to explain these effects. Recent work using a muscle-specific knockout of the upstream kinase, LKB1, has confirmed that the LKB1-->AMPK cascade is the signaling pathway responsible for many of these effects.

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收藏

页码：48 / 60

页数：13

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