Cytokine gene polymorphisms and fatigue in breast cancer survivors: Early findings

被引：117

作者：

Collado-Hidalgo, Alicia ^{[2
]}

Bower, Julienne E. ^{[1
,2
,3
,4
]}

Ganz, Patricia A. ^{[4
,5
,6
]}

Irwin, Michael R. ^{[1
,2
]}

Cole, Steve W. ^{[2
,7
]}

机构：

[1] Univ Calif Los Angeles, Dept Psychiat & Biobehav Sci, Los Angeles, CA 90095 USA

[2] Univ Calif Los Angeles, Semel Inst Neurosci & Human Behav, Cousins Ctr Psychoneuroimmunol, Los Angeles, CA 90095 USA

[3] Univ Calif Los Angeles, Dept Psychol, Los Angeles, CA 90095 USA

[4] Univ Calif Los Angeles, Jonsson Comprehens Canc Ctr, Div Canc Prevent & Control Res, Los Angeles, CA 90095 USA

[5] Univ Calif Los Angeles, Sch Med, Los Angeles, CA 90095 USA

[6] Univ Calif Los Angeles, Sch Publ Hlth, Los Angeles, CA 90095 USA

[7] Univ Calif Los Angeles, Dept Med, Los Angeles, CA 90095 USA

来源：

BRAIN BEHAVIOR AND IMMUNITY | 2008年 / 22卷 / 08期

关键词：

Fatigue; Cancer; Proinflammatory cytokines; Cytokine gene polymorphisms;

D O I：

10.1016/j.bbi.2008.05.009

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 [免疫学];

摘要：

Converging evidence from basic and clinical studies suggests a role for proinflammatory cytokines in cancer-related fatigue, although the etiology of elevated inflammatory processes is unclear. We examined single nucleotide polymorphisms (SNPs) in the promoters of cytokine genes as genetic risk factors for cytokine-related fatigue in 33 fatigued and 14 non-fatigued breast cancer survivors, focusing on promoter sequence polymorphisms in IL1B and IL6 associated with differential expression of proinflammatory cytokines. Predictors of fatigue included presence of at least one cytosine at IL1B -511 (95%Cl = 0.91-16.6, p = .007) and homozyosity for either variant of the IL6 -174 genotype (G/G or C/C; 95%CI = 1.12-17.9, p = .027). Associations between fatigue status and 11,113 genotype remained significant after covariate adjustment for demographic, biobehavioral and treatment-related factors. These findings provide preliminary evidence that polymorphisms in IL1B may serve as a potential risk factor for persistent fatigue in the aftermath of cancer. (C) 2008 Elsevier Inc. All rights reserved.

引用

页码：1197 / 1200

页数：4

共 28 条

[1]

TGFB1 polymorphisms are associated with risk of late normal tissue complications in the breast after radiotherapy for early breast cancer [J].