Prevalence of mefE, erm and tet(M) genes in Streptococcus pneumoniae strains from central Italy

被引：28

作者：

Latini, L

Ronchetti, MP

Merolla, R

Guglielmi, F

Bajaksouzian, S

Villa, MP

Jacobs, MR

Ronchetti, R

机构：

[1] Univ Rome La Sapienza, Dept Pediat, I-00161 Rome, Italy

[2] Univ Rome La Sapienza, Dept Infect Dis, I-00161 Rome, Italy

[3] Case Western Reserve Univ, Dept Pathol, Cleveland, OH 44106 USA

[4] Univ Hosp Cleveland, Cleveland, OH 44106 USA

来源：

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS | 1999年 / 13卷 / 01期

关键词：

Streptococcus pneumoniae; antibiotic resistance genes; Italy;

D O I：

10.1016/S0924-8579(99)00097-7

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

One hundred and seventy-three Streptococcus pneumoniae strains isolated from surveillance studies conducted in daycare centres were studied. The mefE, erm and tet(M) genes were detected in 16.2, 45.1 and 47.4% of isolates respectively. Agreement between PCR results and antibiotic susceptibility patterns was 100%. Macrolide resistance was due to the presence of erm in 73.6% of strains and to the presence of mefE in the remaining 26.4%. All tetracycline resistant strains carried the tet(M) gene, erm was associated with tet(M) in 98.7% of strains, whereas no isolate carrying mefE carried tet(M). A significant association was found between mefE and serogroup 6 (P < 0.0005) and between erm and tet(M) and serogroup 19 (P < 0.00001). (C) 1999 Elsevier Science B.V. and International Society of Chemotherapy. All rights reserved.

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页码：29 / 33

页数：5

相关论文

共 33 条

[1] Emerging resistance to antimicrobial agents in gram-positive bacteria - Pneumococci [J].

Appelbaum, PC .

DRUGS, 1996, 51 :1-5

[2] DETECTION OF ERYTHROMYCIN RESISTANCE BY THE POLYMERASE CHAIN-REACTION USING PRIMERS IN CONSERVED REGIONS OF ERM RIBOSOMAL-RNA METHYLASE GENES [J].

ARTHUR, M ;

MOLINAS, C ;

MABILAT, C ;

COURVALIN, P .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1990, 34 (10) :2024-2026

[3] Antibiotic resistance of pneumococci in Norway [J].

Bergan, T ;

Gaustad, P ;

Hoiby, EA ;

Berdal, BP ;

Furuberg, G ;

Baann, J ;

Tonjum, T .

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 1998, 10 (01) :77-81

[4] CLONING AND ANALYSIS OF THE PROMOTER REGION OF THE ERYTHROMYCIN RESISTANCE GENE (ERME) OF STREPTOMYCES-ERYTHRAEUS [J].

BIBB, MJ ;

JANSSEN, GR ;

WARD, JM .

GENE, 1985, 38 (1-3) :215-226

[5] Antibiotic resistance and serotypes of Streptococcus pneumoniae at Birmingham Public Health Laboratory, 1989-94 [J].

Boswell, TCJ ;

Frodsham, D ;

Nye, KJ ;

Smith, EG .

JOURNAL OF INFECTION, 1996, 33 (01) :17-22

[6] Molecular cloning and functional analysis of a novel macrolide-resistance determinant, mefA, from Streptococcus pyogenes [J].

Clancy, J ;

Petitpas, J ;

DibHajj, F ;

Yuan, W ;

Cronan, M ;

Kamath, AV ;

Bergeron, J ;

Retsema, JA .

MOLECULAR MICROBIOLOGY, 1996, 22 (05) :867-879

[7]

CORNAGLIA G, 1996, EMERG INFECT DIS, V2, P331

[8] Nasopharyngeal colonization in southern Israel with antibiotic-resistant pneumococci during the first 2 years of life: Relation to serotypes likely to be included in pneumococcal conjugate vaccines [J].

Dagan, R ;

Melamed, R ;

Muallem, M ;

Piglansky, L ;

Yagupsky, P .

JOURNAL OF INFECTIOUS DISEASES, 1996, 174 (06) :1352-1355

[9] Variation in erythromycin and clindamycin susceptibilities of Streptococcus pneumoniae by four test methods [J].

Fasola, EI ;

Bajaksouzian, S ;

Appelbaum, PC ;

Jacobs, MR .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1997, 41 (01) :129-134

[10] Antimicrobial susceptibility of Streptococcus pneumoniae isolated from pediatric carriers in Spain [J].

GarciadeLomas, J ;

Gimeno, C ;

Millas, E ;

Bermejo, M ;

Lazaro, MA ;

Navarro, D ;

GarciaPonte, L ;

Garijo, B .

EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES, 1997, 16 (01) :11-13

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