Botanical polysaccharides: Macrophage immunomodulation and therapeutic potential

被引:988
作者
Schepetkin, IA [1 ]
Quinn, MT [1 ]
机构
[1] Montana State Univ, Dept Vet Mol Biol, Bozeman, MT 59717 USA
关键词
immunomodulator; polysaccharide; macrophage; host defense; innate immunity;
D O I
10.1016/j.intimp.2005.10.005
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Botanical polysaccharides exhibit a number of beneficial therapeutic properties, and it is thought that the mechanisms involved in these effects are due to the modulation of innate immunity and, more specifically, macrophage function. In this review, we summarize our current state of understanding of the macrophage modulatory effects of botanical polysaccharides isolated from a wide array of different species of flora, including higher plants, mushrooms, lichens and algae. Overall, the primary effect of botanical polysaccharides is to enhance and/or activate macrophage immune responses, leading to immunomodulation, anti-tumor activity, wound-healing and other therapeutic effects. Furthermore, botanical and microbial polysaccharides bind to common surface receptors and induce similar immunomodulatory responses in macrophages, suggesting that evolutionarily conserved polysaccharide structural features are shared between these organisms. Thus, the evaluation of botanical polysaccharides provides a unique opportunity for the discovery of novel therapeutic agents and adjuvants that exhibit beneficial immunomodulatory properties. (c) 2005 Elsevier B.V. All rights reserved.
引用
收藏
页码:317 / 333
页数:17
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