Combination treatment of human umbilical cord matrix stem cell-based interferon-beta gene therapy and 5-fluorouracil significantly reduces growth of metastatic human breast cancer in SCID mouse lungs

被引：55

作者：

Rachakatla, Raja Shekar ^{[1
]}

Pyle, Marla M. ^{[1
]}

Ayuzawa, Rie ^{[1
]}

Edwards, Sarah M. ^{[1
]}

Marini, Frank C. ^{[2
]}

Weiss, Mark L. ^{[1
]}

Tamura, Masaaki ^{[1
]}

Troyer, Deryl ^{[1
]}

机构：

[1] Kansas State Univ, Dept Anat & Physiol, Manhattan, KS 66506 USA

[2] Univ Texas MD Anderson Canc Ctr, Dept Blood & Marrow Transplantat, Houston, TX 77030 USA

来源：

CANCER INVESTIGATION | 2008年 / 26卷 / 07期

关键词：

interferon-beta; lung tumors; UCMS cells; MDA-231breast carcinoma cells; 5-fluorouracil;

D O I：

10.1080/07357900701871134

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Umbilical cord matrix stem (UCMS) cells that were engineered to express interferon-beta (IFN-beta) were transplanted weekly for three weeks into MDA 231 breast cancer xenografts bearing SCID mice in combination with 5-fluorouracil (5-FU). The UCMS cells were found within lung tumors but not in other tissues. Although both treatments significantly reduced MDA 231 tumor area in the SCID mouse lungs, the combined treatment resulted in a greater reduction in tumor area than by either treatment used alone. These results indicate that a combination treatment of UCMS-IFN-beta cells and 5-FU is a potentially effective therapeutic procedure for breast cancer.

引用

页码：662 / 670

页数：9

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