A functional polymorphism in the prodynorphin gene promotor is associated with temporal lobe epilepsy

被引：88

作者：

Stogmann, E

Zimprich, A

Baumgartner, C

Aull-Watschinger, S

Höllt, V

Zimprich, F

机构：

[1] Univ Hosp Vienna, Dept Neurol, A-1090 Vienna, Austria

[2] Univ Munich, Klinikum Grosshadern, Dept Neurol, Munich, Germany

[3] Otto Von Guericke Univ, Inst Pharmacol & Toxicol, Magdeburg, Germany

来源：

ANNALS OF NEUROLOGY | 2002年 / 51卷 / 02期

关键词：

D O I：

10.1002/ana.10108

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The prodynorphin gene (PDYN) encoding the anticonvulsant peptide dynorphin is a strong candidate for a seizure suppressor gene and thus a possible modulator of susceptibility to temporal lobe epilepsy. We performed a case control association study in 155 patients with nonlesional temporal lobe epilepsy and 202 controls and found that PDYN promotor low-expression L-alleles confer an increased risk for temporal lobe epilepsy in patients with a family history for seizures. Irrespective of the familial background, L-homozygotes display a higher risk for secondarily generalized seizures and status epilepticus.

引用

收藏

页码：260 / 263

页数：4

相关论文

共 21 条

[1] TEMPORAL-LOBE EPILEPSY AFTER PROLONGED FEBRILE CONVULSIONS - EXCELLENT OUTCOME AFTER SURGICAL-TREATMENT [J].

ABOUKHALIL, B ;

ANDERMANN, E ;

ANDERMANN, F ;

OLIVIER, A ;

QUESNEY, LF .

EPILEPSIA, 1993, 34 (05) :878-883

[2]

Berkovic SF, 2000, ANN NEUROL, V47, P557

[3] Familial temporal lobe epilepsy: A common disorder identified in twins [J].

Berkovic, SF ;

McIntosh, A ;

Howell, RA ;

Mitchell, A ;

Sheffield, LJ ;

Hopper, JL .

ANNALS OF NEUROLOGY, 1996, 40 (02) :227-235

[4] A single dose of kainic acid elevates the levels of enkephalins and activator protein-1 transcription factors in the hippocampus for up to 1 year [J].

Bing, GY ;

Wilson, B ;

Hudson, P ;

Jin, L ;

Feng, ZH ;

Zhang, WQ ;

Bing, RJ ;

Hong, JS .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (17) :9422-9427

[5] APOE ε4 genotype is associated with an earlier onset of chronic temporal lobe epilepsy [J].

Briellmann, RS ;

Torn-Broers, Y ;

Busuttil, BE ;

Major, BJ ;

Kalnins, RM ;

Olsen, M ;

Jackson, GD ;

Frauman, AG ;

Berkovic, SF .

NEUROLOGY, 2000, 55 (03) :435-437

[6] Familial temporal lobe epilepsy: A clinically heterogeneous syndrome [J].

Cendes, F ;

Lopes-Cendes, I ;

Andermann, E ;

Andermann, F .

NEUROLOGY, 1998, 50 (02) :554-557

[7] Evidence for a genetic predisposition for status epilepticus [J].

Corey, LA ;

Pellock, JM ;

Boggs, JG ;

Miller, LL ;

DeLorenzo, RJ .

NEUROLOGY, 1998, 50 (02) :558-560

[8]

Elliott RC, 2000, J NEUROSCI, V20, P2142

[9] Family studies and human leukocyte antigen class II typing in Indian probands with seizures in association with single small enhancing computed tomography lesions [J].

Jain, S ;

Padma, MV ;

Kanga, U ;

Mehra, NK ;

Puri, A ;

Maheshwari, MC .

EPILEPSIA, 1999, 40 (02) :232-238

[10]

Kanemoto K, 2000, ANN NEUROL, V47, P571, DOI 10.1002/1531-8249(200005)47:5<571::AID-ANA3>3.3.CO