Neuroprotective properties and mechanisms of erythropoietin in in vitro and in vivo experimental models for hypoxia/ischemia

被引：158

作者：

van der Kooij, Michael A. ^{[1
,2
]}

Groenendaal, Floris ^{[1
]}

Kavelaars, Annemieke ^{[2
]}

Heijnen, Cobi J. ^{[2
]}

van Bel, Frank ^{[1
]}

机构：

[1] Univ Med Ctr Utrecht, Dept Neonatol, NL-3584 EA Utrecht, Netherlands

[2] Univ Med Ctr Utrecht, Lab Psychoneuroimmunol, NL-3584 EA Utrecht, Netherlands

来源：

BRAIN RESEARCH REVIEWS | 2008年 / 59卷 / 01期

关键词：

Erythropoietin; Hypoxia; Ischemia; Mechanism; Neuroprotection; Review;

D O I：

10.1016/j.brainresrev.2008.04.007

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

Besides its established function in erythropoiesis, erythropoietin (EPO) is currently also appreciated for its neuroprotective effects. The detrimental sequelae of prolonged cerebral hypoxia and ischemia have been shown to attenuate by EPO treatment. After binding to the EPO receptor, EPO is capable of initiating a cascade of events which -via different pathways-may lead to neuroprotection. The circumstances that determine which specific signalling route(s) are activated by EPO are largely unknown. We aim to provide the reader with a timely overview on the use of EPO in models of stroke and hypoxia-ischemia and to discuss the molecular events that underlie its neuroprotection. (C) 2008 Elsevier B.V. All rights reserved.

引用

页码：22 / 33

页数：12

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