Nifedipine improves endothelial function role of endothelial progenitor cells

被引：54

作者：

Sugiura, Tomonori ^{[1
,2
,3
,4
]}

Kondo, Takahisa ^{[1
]}

Kureishi-Bando, Yasuko ^{[1
]}

Numaguchi, Yasushi ^{[1
]}

Yoshida, Osamu ^{[1
]}

Dohi, Yasuaki ^{[2
]}

Kimura, Genjiro ^{[2
]}

Ueda, Ryuzo ^{[3
,4
]}

Rabelink, Ton J. ^{[5
]}

Murohara, Toyoaki ^{[1
]}

机构：

[1] Nagoya Univ, Grad Sch Med, Dept Cardiol, Showa Ku, Nagoya, Aichi 4668550, Japan

[2] Nagoya City Univ, Grad Sch Med Sci, Dept Cardiorenal Med & Hypertens, Nagoya, Aichi, Japan

[3] Nagoya City Univ, Grad Sch Med Sci, Dept Internal Med, Nagoya, Aichi, Japan

[4] Nagoya City Univ, Grad Sch Med Sci, Dept Mol Sci, Nagoya, Aichi, Japan

[5] Leiden Univ, Med Ctr, Dept Hypertens & Nephrol, Leiden, Netherlands

来源：

HYPERTENSION | 2008年 / 52卷 / 03期

关键词：

hypertension; endothelial function; endothelial progenitor cell; nifedipine; oxidative stress;

D O I：

10.1161/HYPERTENSIONAHA.108.111914

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

Nifedipine has been shown to improve endothelial function. Recent studies have indicated that endothelial function is correlated with the number of circulating endothelial progenitor cells ( EPCs), but it is unclear whether nifedipine affects the number and function of EPCs. The aims of this study were to determine the effects of nifedipine on the number and function of EPCs and to investigate the relationship between improvement of endothelial function and EPC numbers in patients with hypertension. Stage 1 hypertensive men ( n = 37) were randomly divided into the nifedipine group and the control untreated group. The nifedipine group was administered slow- release nifedipine ( 20 mg) once daily. At baseline and after 4 weeks, flow-mediated dilation, blood pressure, biochemical data, and number of circulating CD34+ CD133+ progenitor cells and EPCs were measured. The direct effects of nifedipine on EPC number and function were assessed in vitro. In the nifedipine group, flow-mediated dilation and the numbers of circulating CD34+ CD133+ progenitor cells and EPCs were increased, along with a decrease of serum malondialdehyde low-density lipoprotein. The improvement of flow-mediated dilation by nifedipine was correlated with the increase of circulating CD34+ CD133+ progenitor cells. Nifedipine also improved angiogenesis- related functions of EPCs ( differentiation, migration, and resistance to oxidative stress) in vitro. Thus, nifedipine improved endothelial function and EPC function in stage 1 hypertensive subjects. The latter action may be mediated by reduction of oxidative stress and suppression of EPC apoptosis. These results demonstrate that nifedipine preserves endothelial integrity in patients with hypertension, at least partly, by enhancing EPC numbers and activity.

引用

页码：491 / 498

页数：8

共 39 条

[11] Antioxidative stress-associated genes in circulating progenitor cells: evidence for enhanced resistance against oxidative stress [J].