A Common Genomic Framework for a Diverse Assembly of Plasmids in the Symbiotic Nitrogen Fixing Bacteria

被引：51

作者：

Crossman, Lisa C. ^{[1
]}

Castillo-Ramirez, Santiago ^{[2
]}

McAnnula, Craig ^{[3
]}

Lozano, Luis ^{[2
]}

Vernikos, Georgios S. ^{[1
]}

Acosta, Jose L. ^{[2
]}

Ghazoui, Zara F. ^{[4
]}

Hernandez-Gonzalez, Ismael ^{[2
]}

Meakin, Georgina ^{[5
]}

Walker, Alan W. ^{[1
]}

Hynes, Michael F. ^{[6
]}

Young, J. Peter W. ^{[4
]}

Downie, J. Allan ^{[3
]}

Romero, David ^{[2
]}

Johnston, Andrew W. B. ^{[5
]}

Davila, Guillermo ^{[2
]}

Parkhill, Julian ^{[1
]}

Gonzalez, Victor ^{[2
]}

机构：

[1] Wellcome Trust Sanger Inst, Cambridge, England

[2] Univ Nacl Autonoma Mexico, Cuernavaca, Morelos, Mexico

[3] John Innes Ctr, Norwich, Norfolk, England

[4] Univ York, Dept Biol, York, N Yorkshire, England

[5] Univ E Anglia, Sch Biol Sci, Norwich, Norfolk, England

[6] Univ Calgary, Dept Biol Sci, Calgary, AB, Canada

来源：

PLOS ONE | 2008年 / 3卷 / 07期

基金：

英国惠康基金; 英国自然环境研究理事会; 英国生物技术与生命科学研究理事会;

关键词：

D O I：

10.1371/journal.pone.0002567

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

This work centres on the genomic comparisons of two closely-related nitrogen-fixing symbiotic bacteria, Rhizobium leguminosarum biovar viciae 3841 and Rhizobium etli CFN42. These strains maintain a stable genomic core that is also common to other rhizobia species plus a very variable and significant accessory component. The chromosomes are highly syntenic, whereas plasmids are related by fewer syntenic blocks and have mosaic structures. The pairs of plasmids p42f-pRL12, p42e-pRL11 and p42b-pRL9 as well large parts of p42c with pRL10 are shown to be similar, whereas the symbiotic plasmids ( p42d and pRL10) are structurally unrelated and seem to follow distinct evolutionary paths. Even though purifying selection is acting on the whole genome, the accessory component is evolving more rapidly. This component is constituted largely for proteins for transport of diverse metabolites and elements of external origin. The present analysis allows us to conclude that a heterogeneous and quickly diversifying group of plasmids co-exists in a common genomic framework.

引用

页数：9

共 36 条

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