Microsatellite polymorphism in the human heme oxygenase-1 gene promoter and its application in association studies with Alzheimer and Parkinson disease

被引：166

作者：

Kimpara, T

Takeda, A

Watanabe, K

Itoyama, Y

Ikawa, S

Watanabe, M

Arai, H

Sasaki, H

Higuchi, S

Okita, N

Takase, S

Saito, H

Takahashi, K

Shibahara, S

机构：

[1] TOHOKU UNIV,SCH MED,DEPT NEUROL,AOBA KU,SENDAI,MIYAGI 98077,JAPAN

[2] TOHOKU UNIV,INST DEV AGING & CANC,DEPT MOL GENET,AOBA KU,SENDAI,MIYAGI 98077,JAPAN

[3] TOHOKU UNIV,SCH MED,DEPT GERIATR,AOBA KU,SENDAI,MIYAGI 98077,JAPAN

[4] KURIHAMA NATL HOSP,NATL INST ALCOHOLISM,DEPT PSYCHIAT,KANAGAWA,JAPAN

[5] KOHNAN HOSP,DEPT NEUROL,SENDAI,MIYAGI,JAPAN

[6] NATL NISHITAGA HOSP,DEPT NEUROL,SENDAI,MIYAGI,JAPAN

[7] TOHOKU UNIV,SCH MED,DEPT APPL PHYSIOL & MOL BIOL,AOBA KU,SENDAI,MIYAGI 98077,JAPAN

来源：

HUMAN GENETICS | 1997年 / 100卷 / 01期

关键词：

D O I：

10.1007/s004390050480

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Oxidative stress has been suggested to be involved in the pathogenesis of neurodegenerative diseases, such as Alzheimer disease (AD) and Parkinson disease (PD). Heme oxygenase-1 (HO-1), a key enzyme in heme catabolism, also functions as an antioxidant enzyme. Here, we show that a (GT)(n) repeat in the human HO-1 gene promoter region is highly polymorphic, although no particular alleles are associated with AD or PD. This newly identified genetic marker should allow us to study the possible involvement of HO-1 in certain human diseases.

引用

页码：145 / 147

页数：3

共 10 条

[1] MUTANT DEBRISOQUINE HYDROXYLATION GENES IN PARKINSONS-DISEASE [J].