Characteristics and Significance of the Pre-metastatic Niche

被引：1239

作者：

Liu, Yang ^{[1
]}

Cao, Xuetao ^{[1
,2
,3
]}

机构：

[1] Chinese Acad Med Sci, Natl Key Lab Med Mol Biol, Dept Immunol, Ctr Immunotherapy,Inst Basic Med Sci,Peking Union, Beijing 100005, Peoples R China

[2] Second Mil Med Univ, Natl Key Lab Med Immunol, Shanghai 200433, Peoples R China

[3] Second Mil Med Univ, Inst Immunol, Shanghai 200433, Peoples R China

来源：

CANCER CELL | 2016年 / 30卷 / 05期

基金：

中国国家自然科学基金;

关键词：

BREAST-CANCER CELLS; TO-MESENCHYMAL TRANSITION; HEPATIC STELLATE CELLS; HUMAN PROSTATE-CANCER; PREMETASTATIC NICHE; PANCREATIC-CANCER; LUNG METASTASIS; STEM-CELLS; PROMOTE METASTASIS; TUMOR PROGRESSION;

D O I：

10.1016/j.ccell.2016.09.011

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Primary tumors create a favorable microenvironment, namely, pre-metastatic niche, in secondary organs and tissue sites for subsequent metastases. The pre-metastatic niche can be primed and established through a complex interplay among primary tumor-derived factors, tumor-mobilized bone marrow-derived cells, and local stromal components. We review here our current understanding of the key components and underlying mechanisms for pre-metastatic niche formation. We propose six characteristics that define the pre-metastatic niche, which enable tumor cell colonization and promote metastasis, including immunosuppression, inflammation, angiogenesis/vascular permeability, lymphangiogenesis, organotropism, and reprogramming. We highlight the significance of the pre-metastatic niche, and discuss potential implications and future research directions.

引用

页码：668 / 681

页数：14

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