Self-regulation and cross-regulation of pattern-recognition receptor signalling in health and disease

被引：486

作者：

Cao, Xuetao ^{[1
,2
,3
,4
]}

机构：

[1] Chinese Acad Med Sci, Inst Basic Med Sci, Natl Key Lab Med Mol Biol, Beijing 100005, Peoples R China

[2] Chinese Acad Med Sci, Inst Basic Med Sci, Dept Immunol, Beijing 100005, Peoples R China

[3] Second Mil Med Univ, Natl Key Lab Med Immunol, Shanghai 200433, Peoples R China

[4] Second Mil Med Univ, Inst Immunol, Shanghai 200433, Peoples R China

来源：

NATURE REVIEWS IMMUNOLOGY | 2016年 / 16卷 / 01期

基金：

中国国家自然科学基金;

关键词：

TOLL-LIKE RECEPTORS; NF-KAPPA-B; NLRP3 INFLAMMASOME ACTIVATION; INNATE IMMUNE-RESPONSES; E3 UBIQUITIN LIGASE; SYSTEMIC-LUPUS-ERYTHEMATOSUS; MODIFYING ENZYME A20; RIG-I; NEGATIVE REGULATION; DENDRITIC CELLS;

D O I：

10.1038/nri.2015.8

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In the initiation of innate immune responses against pathogens, pattern-recognition receptors (PRRs) have an essential role in recognizing specific components of microorganisms and triggering responses that eliminate the invading microorganisms. However, inappropriate activation of PRRs can lead to prolonged inflammation and even to autoimmune and inflammatory diseases. Thus, PRR-triggered responses are regulated through the degradation or translocation of the innate receptors themselves and through the involvement of intracellular regulators or amplifiers. In addition, a complex interplay between PRRs and/or other immune pathways finely tunes the outcome of host immune defence responses. In this Review, I describe many of the numerous distinct mechanisms for the self-regulation and cross-regulation of innate immune receptor signalling.

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页码：35 / 50

页数：16

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