A proton nuclear magnetic resonance study of the interaction of zinc(II) with the antitumour drug streptonigrin

被引：13

作者：

Long, GV ^{[1
]}

Harding, MM ^{[1
]}

机构：

[1] UNIV SYDNEY,SCH CHEM,SYDNEY,NSW 2006,AUSTRALIA

来源：

JOURNAL OF THE CHEMICAL SOCIETY-DALTON TRANSACTIONS | 1996年 / 04期

关键词：

D O I：

10.1039/dt9960000549

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The interaction of zinc(II) with the antitumour drug streptonigrin in [H-2(8)]tetrahydrofuran has been studied by 400 MHz variable-temperature H-1 NMR spectroscopy. kf 190 K, and in the presence of an excess of zinc(II) trifluoromethanesulfonate (triflate); (10-15 equivalents);streptonigrin forms a 1:1 complex Ia(6%) and two diastereomeric 2: 1 complexes, Ib (15%) and Ic (79%). The relative concentrations of these complexes are highly temperature dependent and at room temperature only la is detected. A fourth minor complex Id was detected (< 5%) in the range 240-260 K. In CD3CN and less than 5 equivalents of zinc(II) triflate, la-ld are detected, but in the presence of 10-15 equivalents of zinc(rr) triflate la is the predominant complex (> 93%) in the range 235-300 K. Implications for the role of metal ions in the mechanism of the antitumour action of streptonigrin are discussed.

引用

页码：549 / 552

页数：4

共 33 条

[11] SOLUTION CONFORMATION OF THE ANTITUMOR DRUG STREPTONIGRIN [J].