Liquid chromatography and mass spectrometry of haem biosynthetic intermediates: a review

被引：6

作者：

Benton, Christopher M. ^{[1
,2
]}

Lim, Chang Kee ^{[1
]}

机构：

[1] Kings Coll Hosp London, London SE5 9RS, England

[2] Univ Leicester, RKCSB, Leicester LE2 7LX, Leics, England

来源：

BIOMEDICAL CHROMATOGRAPHY | 2012年 / 26卷 / 08期

关键词：

5-aminolaevulinic acid; porphobilinogen; porphyrinogens; porphyrins; porphyrias; liquid chromatography; mass spectrometry; DELTA-AMINOLEVULINIC-ACID; PORPHYRIN CARBOXYLIC-ACIDS; RAT HARDERIAN-GLAND; IN-VITRO ASSESSMENT; HUMAN-BONE MARROW; 5-AMINOLEVULINIC ACID; CAPILLARY-ELECTROPHORESIS; URINARY PORPHYRINS; UROPORPHYRINOGEN DECARBOXYLASE; QUANTITATIVE-DETERMINATION;

D O I：

10.1002/bmc.2772

中图分类号：

Q5 [生物化学];

学科分类号：

070307 [化学生物学];

摘要：

This article discusses the separation, analysis and characterisation of intermediates and oxidative by-products of the haem biosynthetic pathway by liquid chromatography and mass spectrometry. Techniques reviewed include high-performance liquid chromatography, ultra-high-performance liquid chromatography, capillary electrophoresis, ion mobility spectrometry, mass spectrometry and tandem mass spectrometry. The emphasis was on the analysis of biological and clinical samples. Copyright (c) 2012 John Wiley & Sons, Ltd.

引用

页码：1009 / 1023

页数：15

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