Chemical and enzymatic synthesis and antiviral properties of 2′-deoxy-2′-fluoroguanosine

被引：17

作者：

Zaitseva, GV

Zinchenko, AI

Barai, VN

Pavlova, NI

Boreko, EI

Mikhailopulo, IA

机构：

[1] Natl Acad Sci, Inst Bioorgan Chem, Minsk 220141, BELARUS

[2] Natl Acad Sci, Inst Microbiol, Minsk 220141, BELARUS

[3] Byelorrussian Res Inst Epidemiol & Microbiol, Minsk 220050, BELARUS

来源：

NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS | 1999年 / 18卷 / 4-5期

关键词：

D O I：

10.1080/15257779908041541

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Chemical and enzymatic methods were employed for the synthesis of the title compound, 2'F-Guo 7. High antiviral activity of 2'F-Guo was established in chick embryo cells infected with influenza virus FPV/Rostock/34 (H7N1) and herpes simplex virus (HSV) type I (1C strain).

引用

页码：687 / 688

页数：2

共 5 条

[1] OXIDATION-REDUCTION SEQUENCE FOR THE SYNTHESIS OF PERACYLATED FLUORODEOXY PENTOFURANOSIDES [J].