Autoantibodies against type I IFNs in patients with life-threatening COVID-19

被引：1919

作者：

Bastard, Paul ^{[1
,2
,3
]}

Rosen, Lindsey B. ^{[4
]}

Zhang, Qian ^{[3
]}

Michailidis, Eleftherios ^{[5
]}

Hoffmann, Hans-Heinrich ^{[5
]}

Zhang, Yu ^{[4
]}

Dorgham, Karim ^{[6
]}

Philippot, Quentin ^{[1
,2
]}

Rosain, Jeremie ^{[1
,2
]}

Beziat, Vivien ^{[1
,2
,3
]}

Manry, Jeremy ^{[1
,2
]}

Shaw, Elana ^{[4
]}

Haljasmagi, Liis ^{[7
]}

Peterson, Part ^{[7
]}

Lorenzo, Lazaro ^{[1
,2
]}

Bizien, Lucy ^{[1
,2
]}

Trouillet-Assant, Sophie ^{[8
,9
]}

Dobbs, Kerry ^{[4
]}

de Jesus, Adriana Almeida ^{[4
]}

Belot, Alexandre ^{[9
,10
,11
]}

Kallaste, Anne ^{[12
]}

Catherinot, Emilie ^{[13
]}

Tandjaoui-Lambiotte, Yacine ^{[14
]}

Le Pen, Jeremie ^{[5
]}

Kerner, Gaspard ^{[1
,2
]}

Bigio, Benedetta ^{[3
]}

Seeleuthner, Yoann ^{[1
,2
]}

Yang, Rui ^{[3
]}

Bolze, Alexandre ^{[15
]}

Spaan, Andras N. ^{[3
,16
]}

Delmonte, Ottavia M. ^{[4
]}

Abers, Michael S. ^{[4
]}

Aiuti, Alessandro ^{[17
,18
]}

Casari, Giorgio ^{[17
,18
]}

Lampasona, Vito ^{[17
,18
]}

Piemonti, Lorenzo ^{[17
,18
]}

Ciceri, Fabio ^{[17
,18
]}

Bilguvar, Kaya ^{[19
]}

Lifton, Richard P. ^{[19
,20
,21
]}

Vasse, Marc ^{[22
,23
]}

Smadja, David M. ^{[24
,25
]}

Migaud, Melanie ^{[1
,2
]}

Hadjadj, Jerome ^{[26
]}

Terrier, Benjamin ^{[27
]}

Duffy, Darragh ^{[28
]}

Quintana-Murci, Lluis ^{[29
,30
]}

van de Beek, Diederik ^{[31
]}

Roussel, Lucie ^{[32
,33
]}

Vinh, Donald C. ^{[32
,33
]}

Tangye, Stuart G. ^{[34
,35
]}

机构：

[1] Necker Hosp Sick Children, Lab Human Genet Infect Dis, Necker Branch, INSERM U1163, Paris, France

[2] Univ Paris, Imagine Inst, Paris, France

[3] Rockefeller Univ, St Giles Lab Human Genet Infect Dis, Rockefeller Branch, 1230 York Ave, New York, NY 10021 USA

[4] NIAID, Lab Clin Immunol & Microbiol, Div Intramural Res, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA

[5] Rockefeller Univ, Lab Virol & Infect Dis, 1230 York Ave, New York, NY 10021 USA

[6] Sorbonne Univ, INSERM, Ctr Immunol & Malad Infect CIMI Paris, Paris, France

[7] Univ Tartu, Inst Biomed & Translat Med, Tartu, Estonia

[8] Hosp Civils Lyon, Lyon Sud Hosp, Pierre Benite, France

[9] Lyon Univ, Int Ctr Res Infectiol, INSERM U1111, CNRS UMR 5308,ENS,UCBL, Lyon, France

[10] Natl Referee Ctr Rheumat & AutoImmune & System Di, Lyon, France

[11] Hosp Civils Lyon, Lyon Immunopathol Federat LIFE, Lyon, France

[12] Tartu Univ Hosp, Internal Med Clin, Tartu, Estonia

[13] Foch Hosp, Dept Pneumol, Suresne, France

[14] Avicenne Hosp, AP HP, INSERM U1272 Hypoxia & Lung, Bobigny, France

[15] Helix, San Mateo, CA USA

[16] Univ Med Ctr Utrecht, Dept Med Microbiol, Utrecht, Netherlands

[17] IRCCS San Raffaele Hosp, Milan, Italy

[18] Univ Vita Salute San Raffaele, Milan, Italy

[19] Yale Univ, Sch Med, Dept Genet, New Haven, CT 06510 USA

[20] Yale Univ, Sch Med, Yale Ctr Genome Anal, New Haven, CT USA

[21] Rockefeller Univ, Lab Human Genet & Genom, 1230 York Ave, New York, NY 10021 USA

[22] Hop Foch, Serv Biol Clin, Suresnes, France

[23] Hop Foch, UMR S 1176, Suresnes, France

[24] Univ Paris, INSERM UMR S 1140, Biosurg Res Lab, Carpentier Fdn, Paris, France

[25] Hop Europeen Georges Pompidou, Paris, France

[26] Univ Paris, Imagine Inst, Lab Immunogenet Pediat Autoimmune Dis, INSERM UMR 1163, Paris, France

[27] Univ Paris, Dept Internal Med, Natl Referral Ctr Rare System Autoimmune Dis, AP HP,Ctr APHP CUP, Paris, France

[28] Inst Pasteur, Translat Immunol Lab, Paris, France

[29] Inst Pasteur, Human Evolutionary Genet Unit, CNRS UMR 2000, F-75015 Paris, France

[30] Coll France, Human Genom & Evolut, Paris, France

[31] Univ Amsterdam, Dept Neurol, Amsterdam UMC, Amsterdam Neurosci, Amsterdam, Netherlands

[32] McGill Univ, Ctr Hlth, Div Infect Dis, Dept Med, Montreal, PQ, Canada

[33] McGill Univ, Ctr Hlth, Infect Dis Susceptibil Program, Res Inst, Montreal, PQ, Canada

[34] Garvan Inst Med Res, Sydney, NSW 2010, Australia

[35] Univ New South Wales Sydney, Fac Med, St Vincents Clin Sch, Darlinghurst, NSW 2010, Australia

[36] Ghent Univ Hosp, Dept Paediat Immunol & Pulmonol, Ctr Primary Immunodeficiency Ghent CPIG, PID Res Lab,Jeffrey Modell Diag & Res Ctr, Ghent, Belgium

[37] Univ Barcelona, Infect Dis & HIV Serv, Fdn Docencia & Recerca Mutua Terrassa, Hosp Univ Mutua Terrassa, Barcelona, Catalonia, Spain

[38] IrsiCaixa AIDS Res Inst, Badalona, Spain

[39] Inst Hlth Sci Res Germans Trias & Pujol IGTP, Badalona, Spain

[40] Univ Vic Central Univ Catalonia UVic UCC, Fac Med, Ctr Hlth & Social Care Res CESS, Infect Dis & Immun, Vic, Spain

[41] Catalan Inst Res & Adv Studies ICREA, Barcelona, Spain

[42] Karolinska Inst, Dept Womens & Childrens Hlth, Sci Life Lab, Karolinska, Sweden

[43] Karolinska Univ Hosp, Dept Pediat Rheumatol, Karolinska, Sweden

[44] Rockefeller Univ, Lab Mol Immunol, 1230 York Ave, New York, NY 10021 USA

[45] Howard Hughes Med Inst, New York, NY 10065 USA

[46] Hosp Univ Gran Canaria Dr Negrin, Canarian Hlth Syst, Dept Immunol, Las Palmas Gran Canaria, Spain

[47] Univ Fernando Pessoa Canarias, Dept Clin Sci, Las Palmas Gran Canaria, Spain

[48] Univ Paris, Neglected Human Genet Lab, INSERM, Paris, France

[49] Aarhus Univ Hosp, Dept Infect Dis, Skejby, Denmark

[50] Aarhus Univ, Dept Biomed, Aarhus, Denmark

来源：

SCIENCE | 2020年 / 370卷 / 6515期

基金：

美国国家卫生研究院; 英国医学研究理事会;

关键词：

CHRONIC MUCOCUTANEOUS CANDIDIASIS; INTERFERON; ANTIBODIES; DISEASE; CYTOKINES; PROTEINS; GAMMA;

D O I：

10.1126/science.abd4585

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

070301 [无机化学]; 070403 [天体物理学]; 070507 [自然资源与国土空间规划学]; 090105 [作物生产系统与生态工程];

摘要：

Interindividual clinical variability in the course of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is vast. We report that at least 101 of 987 patients with life-threatening coronavirus disease 2019 (COVID-19) pneumonia had neutralizing immunoglobulin G (IgG) autoantibodies (auto-Abs) against interferon-omega (IFN-omega) (13 patients), against the 13 types of IFN-alpha (36), or against both (52) at the onset of critical disease; a few also had auto-Abs against the other three type I IFNs. The auto-Abs neutralize the ability of the corresponding type I IFNs to block SARS-CoV-2 infection in vitro. These auto-Abs were not found in 663 individuals with asymptomatic or mild SARS-CoV-2 infection and were present in only 4 of 1227 healthy individuals. Patients with auto-Abs were aged 25 to 87 years and 95 of the 101 were men. A B cell autoimmune phenocopy of inborn errors of type I IFN immunity accounts for lifethreatening COVID-19 pneumonia in at least 2.6% of women and 12.5% of men.

引用

页码：423 / +

页数：13

共 45 条

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A COVID-19 pneumonia case report of autoimmune polyendocrine syndrome type 1 in Lombardy, Italy: letter to the editor [J].