Adjuvants for human vaccines

被引：173

作者：

Alving, Carl R. ^{[1
]}

Peachman, Kristina K. ^{[1
]}

Rao, Mangala ^{[1
]}

Reed, Steven G. ^{[2
]}

机构：

[1] Walter Reed Army Inst Res, US Mil HIV Res Program, Lab Adjuvant & Antigen Res, Silver Spring, MD 20910 USA

[2] Infect Dis Res Inst, Seattle, WA 98104 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 2012年 / 24卷 / 03期

关键词：

MALARIA VACCINE; TRANSCUTANEOUS IMMUNIZATION; EPICUTANEOUS IMMUNIZATION; INFLUENZA VACCINE; ANIMAL-MODELS; IMMUNITY; TUBERCULOSIS; INDUCTION; LIPOSOMES; EMULSION;

D O I：

10.1016/j.coi.2012.03.008

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Rational selection of individual adjuvants can often be made on the basis of innate molecular interactions of the foreign molecules with pattern recognition receptors such as Toll-like receptors. For example, monophosphoryl lipid A, a family of endotoxic TLR4 agonist molecules from bacteria, has recently been formulated with liposomes, oil emulsions, or aluminum salts for several vaccines. Combinations of antigens and adjuvants with particulate lipid or oil components may reveal unique properties of immune potency or efficacy, but these can sometimes be exhibited differently in rodents when compared to nonhuman primates or humans. New adjuvants, formulations, microinjection devices, and skin delivery techniques for transcutaneous immunization demonstrate that adjuvant systems can include combinations of strategies and delivery mechanisms for uniquely formulated antigens and adjuvants.

引用

页码：310 / 315

页数：6

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