机构:
Royal Melbourne Hosp, Walter & Eliza Hall Inst Med Res, Parkville, Vic 3050, AustraliaRoyal Melbourne Hosp, Walter & Eliza Hall Inst Med Res, Parkville, Vic 3050, Australia
Lessene, Guillaume
[1
]
Czabotar, Peter E.
论文数: 0引用数: 0
h-index: 0
机构:
Royal Melbourne Hosp, Walter & Eliza Hall Inst Med Res, Parkville, Vic 3050, AustraliaRoyal Melbourne Hosp, Walter & Eliza Hall Inst Med Res, Parkville, Vic 3050, Australia
Czabotar, Peter E.
[1
]
Colman, Peter M.
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h-index: 0
机构:
Royal Melbourne Hosp, Walter & Eliza Hall Inst Med Res, Parkville, Vic 3050, AustraliaRoyal Melbourne Hosp, Walter & Eliza Hall Inst Med Res, Parkville, Vic 3050, Australia
Colman, Peter M.
[1
]
机构:
[1] Royal Melbourne Hosp, Walter & Eliza Hall Inst Med Res, Parkville, Vic 3050, Australia
Overexpression of members of the BCL-2 family of pro-survival proteins is commonly associated with unfavourable pathogenesis in cancer. The convergence of cytotoxic stress signals on the extended BCL-2 protein family provides the biological rationale for directly targeting this family to induce apoptotic cell death. Recently, several compounds have been described that inhibit the interaction between BCL- 2 family members and their natural ligand, a helical peptide sequence known as the BH3 domain. Here, we review preclinical and clinical data on these compounds, and recommend four criteria that define antagonists of the BCL-2 protein family.
机构:
Walter & Eliza Hall Inst Med Res, Dept Mol Genet Canc, Parkville, Vic 3050, AustraliaWalter & Eliza Hall Inst Med Res, Dept Mol Genet Canc, Parkville, Vic 3050, Australia
Adams, J. M.
Cory, S.
论文数: 0引用数: 0
h-index: 0
机构:
Walter & Eliza Hall Inst Med Res, Dept Mol Genet Canc, Parkville, Vic 3050, AustraliaWalter & Eliza Hall Inst Med Res, Dept Mol Genet Canc, Parkville, Vic 3050, Australia
机构:Univ Birmingham, Canc Res UK Inst Canc Studies, Birmingham B15 2TT, W Midlands, England
Alvi, AJ
Austen, B
论文数: 0引用数: 0
h-index: 0
机构:Univ Birmingham, Canc Res UK Inst Canc Studies, Birmingham B15 2TT, W Midlands, England
Austen, B
Weston, VJ
论文数: 0引用数: 0
h-index: 0
机构:Univ Birmingham, Canc Res UK Inst Canc Studies, Birmingham B15 2TT, W Midlands, England
Weston, VJ
Fegan, C
论文数: 0引用数: 0
h-index: 0
机构:Univ Birmingham, Canc Res UK Inst Canc Studies, Birmingham B15 2TT, W Midlands, England
Fegan, C
MacCallum, D
论文数: 0引用数: 0
h-index: 0
机构:Univ Birmingham, Canc Res UK Inst Canc Studies, Birmingham B15 2TT, W Midlands, England
MacCallum, D
Gianella-Borradori, A
论文数: 0引用数: 0
h-index: 0
机构:Univ Birmingham, Canc Res UK Inst Canc Studies, Birmingham B15 2TT, W Midlands, England
Gianella-Borradori, A
Lane, DP
论文数: 0引用数: 0
h-index: 0
机构:Univ Birmingham, Canc Res UK Inst Canc Studies, Birmingham B15 2TT, W Midlands, England
Lane, DP
Hubank, M
论文数: 0引用数: 0
h-index: 0
机构:Univ Birmingham, Canc Res UK Inst Canc Studies, Birmingham B15 2TT, W Midlands, England
Hubank, M
Powell, JE
论文数: 0引用数: 0
h-index: 0
机构:Univ Birmingham, Canc Res UK Inst Canc Studies, Birmingham B15 2TT, W Midlands, England
Powell, JE
Wei, WB
论文数: 0引用数: 0
h-index: 0
机构:Univ Birmingham, Canc Res UK Inst Canc Studies, Birmingham B15 2TT, W Midlands, England
Wei, WB
Taylor, AMR
论文数: 0引用数: 0
h-index: 0
机构:Univ Birmingham, Canc Res UK Inst Canc Studies, Birmingham B15 2TT, W Midlands, England
Taylor, AMR
Moss, PAH
论文数: 0引用数: 0
h-index: 0
机构:Univ Birmingham, Canc Res UK Inst Canc Studies, Birmingham B15 2TT, W Midlands, England
Moss, PAH
Stankovic, T
论文数: 0引用数: 0
h-index: 0
机构:
Univ Birmingham, Canc Res UK Inst Canc Studies, Birmingham B15 2TT, W Midlands, EnglandUniv Birmingham, Canc Res UK Inst Canc Studies, Birmingham B15 2TT, W Midlands, England
机构:
Wayne State Univ, Sch Med, Dept Internal Med, Div Hematol Oncol, Detroit, MI 48202 USAWayne State Univ, Sch Med, Dept Internal Med, Div Hematol Oncol, Detroit, MI 48202 USA
Arnold, Alan A.
Aboukameel, Amro
论文数: 0引用数: 0
h-index: 0
机构:
Wayne State Univ, Sch Med, Dept Internal Med, Div Hematol Oncol, Detroit, MI 48202 USAWayne State Univ, Sch Med, Dept Internal Med, Div Hematol Oncol, Detroit, MI 48202 USA
Aboukameel, Amro
Chen, Jianyong
论文数: 0引用数: 0
h-index: 0
机构:
Univ Michigan, Ctr Comprehens Canc, Dept Internal Med & Med Chem, Ann Arbor, MI USAWayne State Univ, Sch Med, Dept Internal Med, Div Hematol Oncol, Detroit, MI 48202 USA
Chen, Jianyong
Yang, Dajun
论文数: 0引用数: 0
h-index: 0
机构:
Ascenta Therapeut Inc, Malvern, PA USAWayne State Univ, Sch Med, Dept Internal Med, Div Hematol Oncol, Detroit, MI 48202 USA
Yang, Dajun
Wang, Shaomeng
论文数: 0引用数: 0
h-index: 0
机构:
Univ Michigan, Ctr Comprehens Canc, Dept Internal Med & Med Chem, Ann Arbor, MI USAWayne State Univ, Sch Med, Dept Internal Med, Div Hematol Oncol, Detroit, MI 48202 USA
Wang, Shaomeng
Al-Katib, Ayad
论文数: 0引用数: 0
h-index: 0
机构:
Wayne State Univ, Sch Med, Dept Internal Med, Div Hematol Oncol, Detroit, MI 48202 USAWayne State Univ, Sch Med, Dept Internal Med, Div Hematol Oncol, Detroit, MI 48202 USA
Al-Katib, Ayad
Mohammad, Ramzi M.
论文数: 0引用数: 0
h-index: 0
机构:
Wayne State Univ, Sch Med, Dept Internal Med, Div Hematol Oncol, Detroit, MI 48202 USAWayne State Univ, Sch Med, Dept Internal Med, Div Hematol Oncol, Detroit, MI 48202 USA
机构:
Royal Melbourne Hosp, Mol Genet Canc Div, Walter & Eliza Hall Inst Med Res, Melbourne, Vic 3050, AustraliaRoyal Melbourne Hosp, Mol Genet Canc Div, Walter & Eliza Hall Inst Med Res, Melbourne, Vic 3050, Australia
Baell, JB
Huang, DCS
论文数: 0引用数: 0
h-index: 0
机构:
Royal Melbourne Hosp, Mol Genet Canc Div, Walter & Eliza Hall Inst Med Res, Melbourne, Vic 3050, AustraliaRoyal Melbourne Hosp, Mol Genet Canc Div, Walter & Eliza Hall Inst Med Res, Melbourne, Vic 3050, Australia
机构:
Univ Calif San Diego, Moores Canc Ctr, La Jolla, CA 92093 USA
Univ Calif San Diego, Chronic Lymphocyt Leukemia Res Consortium, La Jolla, CA 92093 USAUniv Calif San Diego, Moores Canc Ctr, La Jolla, CA 92093 USA
Castro, Januario E.
Loria, Olivier J.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Diego, Moores Canc Ctr, La Jolla, CA 92093 USA
Univ Calif San Diego, Chronic Lymphocyt Leukemia Res Consortium, La Jolla, CA 92093 USAUniv Calif San Diego, Moores Canc Ctr, La Jolla, CA 92093 USA
Loria, Olivier J.
Aguillon, Robier A.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Diego, Moores Canc Ctr, La Jolla, CA 92093 USA
Univ Calif San Diego, Chronic Lymphocyt Leukemia Res Consortium, La Jolla, CA 92093 USAUniv Calif San Diego, Moores Canc Ctr, La Jolla, CA 92093 USA
Aguillon, Robier A.
James, Danelle
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Diego, Moores Canc Ctr, La Jolla, CA 92093 USA
Univ Calif San Diego, Chronic Lymphocyt Leukemia Res Consortium, La Jolla, CA 92093 USAUniv Calif San Diego, Moores Canc Ctr, La Jolla, CA 92093 USA
James, Danelle
Llanos, Cesar A.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Diego, Moores Canc Ctr, La Jolla, CA 92093 USA
Univ Calif San Diego, Chronic Lymphocyt Leukemia Res Consortium, La Jolla, CA 92093 USAUniv Calif San Diego, Moores Canc Ctr, La Jolla, CA 92093 USA
Llanos, Cesar A.
Rassenti, Laura
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Diego, Moores Canc Ctr, La Jolla, CA 92093 USA
Univ Calif San Diego, Chronic Lymphocyt Leukemia Res Consortium, La Jolla, CA 92093 USAUniv Calif San Diego, Moores Canc Ctr, La Jolla, CA 92093 USA
Rassenti, Laura
Wood, Brian A.
论文数: 0引用数: 0
h-index: 0
机构:
ASCENTA Therapeut Inc, San Diego, CA USAUniv Calif San Diego, Moores Canc Ctr, La Jolla, CA 92093 USA
Wood, Brian A.
Homlund, Jon T.
论文数: 0引用数: 0
h-index: 0
机构:
ASCENTA Therapeut Inc, San Diego, CA USAUniv Calif San Diego, Moores Canc Ctr, La Jolla, CA 92093 USA
Homlund, Jon T.
Kipps, Thomas J.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Diego, Moores Canc Ctr, La Jolla, CA 92093 USA
Univ Calif San Diego, Chronic Lymphocyt Leukemia Res Consortium, La Jolla, CA 92093 USAUniv Calif San Diego, Moores Canc Ctr, La Jolla, CA 92093 USA
机构:
Walter & Eliza Hall Inst Med Res, Dept Mol Genet Canc, Parkville, Vic 3050, AustraliaWalter & Eliza Hall Inst Med Res, Dept Mol Genet Canc, Parkville, Vic 3050, Australia
Adams, J. M.
Cory, S.
论文数: 0引用数: 0
h-index: 0
机构:
Walter & Eliza Hall Inst Med Res, Dept Mol Genet Canc, Parkville, Vic 3050, AustraliaWalter & Eliza Hall Inst Med Res, Dept Mol Genet Canc, Parkville, Vic 3050, Australia
机构:Univ Birmingham, Canc Res UK Inst Canc Studies, Birmingham B15 2TT, W Midlands, England
Alvi, AJ
Austen, B
论文数: 0引用数: 0
h-index: 0
机构:Univ Birmingham, Canc Res UK Inst Canc Studies, Birmingham B15 2TT, W Midlands, England
Austen, B
Weston, VJ
论文数: 0引用数: 0
h-index: 0
机构:Univ Birmingham, Canc Res UK Inst Canc Studies, Birmingham B15 2TT, W Midlands, England
Weston, VJ
Fegan, C
论文数: 0引用数: 0
h-index: 0
机构:Univ Birmingham, Canc Res UK Inst Canc Studies, Birmingham B15 2TT, W Midlands, England
Fegan, C
MacCallum, D
论文数: 0引用数: 0
h-index: 0
机构:Univ Birmingham, Canc Res UK Inst Canc Studies, Birmingham B15 2TT, W Midlands, England
MacCallum, D
Gianella-Borradori, A
论文数: 0引用数: 0
h-index: 0
机构:Univ Birmingham, Canc Res UK Inst Canc Studies, Birmingham B15 2TT, W Midlands, England
Gianella-Borradori, A
Lane, DP
论文数: 0引用数: 0
h-index: 0
机构:Univ Birmingham, Canc Res UK Inst Canc Studies, Birmingham B15 2TT, W Midlands, England
Lane, DP
Hubank, M
论文数: 0引用数: 0
h-index: 0
机构:Univ Birmingham, Canc Res UK Inst Canc Studies, Birmingham B15 2TT, W Midlands, England
Hubank, M
Powell, JE
论文数: 0引用数: 0
h-index: 0
机构:Univ Birmingham, Canc Res UK Inst Canc Studies, Birmingham B15 2TT, W Midlands, England
Powell, JE
Wei, WB
论文数: 0引用数: 0
h-index: 0
机构:Univ Birmingham, Canc Res UK Inst Canc Studies, Birmingham B15 2TT, W Midlands, England
Wei, WB
Taylor, AMR
论文数: 0引用数: 0
h-index: 0
机构:Univ Birmingham, Canc Res UK Inst Canc Studies, Birmingham B15 2TT, W Midlands, England
Taylor, AMR
Moss, PAH
论文数: 0引用数: 0
h-index: 0
机构:Univ Birmingham, Canc Res UK Inst Canc Studies, Birmingham B15 2TT, W Midlands, England
Moss, PAH
Stankovic, T
论文数: 0引用数: 0
h-index: 0
机构:
Univ Birmingham, Canc Res UK Inst Canc Studies, Birmingham B15 2TT, W Midlands, EnglandUniv Birmingham, Canc Res UK Inst Canc Studies, Birmingham B15 2TT, W Midlands, England
机构:
Wayne State Univ, Sch Med, Dept Internal Med, Div Hematol Oncol, Detroit, MI 48202 USAWayne State Univ, Sch Med, Dept Internal Med, Div Hematol Oncol, Detroit, MI 48202 USA
Arnold, Alan A.
Aboukameel, Amro
论文数: 0引用数: 0
h-index: 0
机构:
Wayne State Univ, Sch Med, Dept Internal Med, Div Hematol Oncol, Detroit, MI 48202 USAWayne State Univ, Sch Med, Dept Internal Med, Div Hematol Oncol, Detroit, MI 48202 USA
Aboukameel, Amro
Chen, Jianyong
论文数: 0引用数: 0
h-index: 0
机构:
Univ Michigan, Ctr Comprehens Canc, Dept Internal Med & Med Chem, Ann Arbor, MI USAWayne State Univ, Sch Med, Dept Internal Med, Div Hematol Oncol, Detroit, MI 48202 USA
Chen, Jianyong
Yang, Dajun
论文数: 0引用数: 0
h-index: 0
机构:
Ascenta Therapeut Inc, Malvern, PA USAWayne State Univ, Sch Med, Dept Internal Med, Div Hematol Oncol, Detroit, MI 48202 USA
Yang, Dajun
Wang, Shaomeng
论文数: 0引用数: 0
h-index: 0
机构:
Univ Michigan, Ctr Comprehens Canc, Dept Internal Med & Med Chem, Ann Arbor, MI USAWayne State Univ, Sch Med, Dept Internal Med, Div Hematol Oncol, Detroit, MI 48202 USA
Wang, Shaomeng
Al-Katib, Ayad
论文数: 0引用数: 0
h-index: 0
机构:
Wayne State Univ, Sch Med, Dept Internal Med, Div Hematol Oncol, Detroit, MI 48202 USAWayne State Univ, Sch Med, Dept Internal Med, Div Hematol Oncol, Detroit, MI 48202 USA
Al-Katib, Ayad
Mohammad, Ramzi M.
论文数: 0引用数: 0
h-index: 0
机构:
Wayne State Univ, Sch Med, Dept Internal Med, Div Hematol Oncol, Detroit, MI 48202 USAWayne State Univ, Sch Med, Dept Internal Med, Div Hematol Oncol, Detroit, MI 48202 USA
机构:
Royal Melbourne Hosp, Mol Genet Canc Div, Walter & Eliza Hall Inst Med Res, Melbourne, Vic 3050, AustraliaRoyal Melbourne Hosp, Mol Genet Canc Div, Walter & Eliza Hall Inst Med Res, Melbourne, Vic 3050, Australia
Baell, JB
Huang, DCS
论文数: 0引用数: 0
h-index: 0
机构:
Royal Melbourne Hosp, Mol Genet Canc Div, Walter & Eliza Hall Inst Med Res, Melbourne, Vic 3050, AustraliaRoyal Melbourne Hosp, Mol Genet Canc Div, Walter & Eliza Hall Inst Med Res, Melbourne, Vic 3050, Australia
机构:
Univ Calif San Diego, Moores Canc Ctr, La Jolla, CA 92093 USA
Univ Calif San Diego, Chronic Lymphocyt Leukemia Res Consortium, La Jolla, CA 92093 USAUniv Calif San Diego, Moores Canc Ctr, La Jolla, CA 92093 USA
Castro, Januario E.
Loria, Olivier J.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Diego, Moores Canc Ctr, La Jolla, CA 92093 USA
Univ Calif San Diego, Chronic Lymphocyt Leukemia Res Consortium, La Jolla, CA 92093 USAUniv Calif San Diego, Moores Canc Ctr, La Jolla, CA 92093 USA
Loria, Olivier J.
Aguillon, Robier A.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Diego, Moores Canc Ctr, La Jolla, CA 92093 USA
Univ Calif San Diego, Chronic Lymphocyt Leukemia Res Consortium, La Jolla, CA 92093 USAUniv Calif San Diego, Moores Canc Ctr, La Jolla, CA 92093 USA
Aguillon, Robier A.
James, Danelle
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Diego, Moores Canc Ctr, La Jolla, CA 92093 USA
Univ Calif San Diego, Chronic Lymphocyt Leukemia Res Consortium, La Jolla, CA 92093 USAUniv Calif San Diego, Moores Canc Ctr, La Jolla, CA 92093 USA
James, Danelle
Llanos, Cesar A.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Diego, Moores Canc Ctr, La Jolla, CA 92093 USA
Univ Calif San Diego, Chronic Lymphocyt Leukemia Res Consortium, La Jolla, CA 92093 USAUniv Calif San Diego, Moores Canc Ctr, La Jolla, CA 92093 USA
Llanos, Cesar A.
Rassenti, Laura
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Diego, Moores Canc Ctr, La Jolla, CA 92093 USA
Univ Calif San Diego, Chronic Lymphocyt Leukemia Res Consortium, La Jolla, CA 92093 USAUniv Calif San Diego, Moores Canc Ctr, La Jolla, CA 92093 USA
Rassenti, Laura
Wood, Brian A.
论文数: 0引用数: 0
h-index: 0
机构:
ASCENTA Therapeut Inc, San Diego, CA USAUniv Calif San Diego, Moores Canc Ctr, La Jolla, CA 92093 USA
Wood, Brian A.
Homlund, Jon T.
论文数: 0引用数: 0
h-index: 0
机构:
ASCENTA Therapeut Inc, San Diego, CA USAUniv Calif San Diego, Moores Canc Ctr, La Jolla, CA 92093 USA
Homlund, Jon T.
Kipps, Thomas J.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Diego, Moores Canc Ctr, La Jolla, CA 92093 USA
Univ Calif San Diego, Chronic Lymphocyt Leukemia Res Consortium, La Jolla, CA 92093 USAUniv Calif San Diego, Moores Canc Ctr, La Jolla, CA 92093 USA