No association of alpha-2 macroglobulin gene five-nucleotide deletion with AD in Taiwan Chinese

被引：19

作者：

Hu, CJ

Sung, SM

Liu, HC

Lee, KY

Hsu, WC

Wong, WK

Lee, CC

Tsai, CH

Chang, JG

机构：

[1] China Med Coll Hosp, Dept Med Res, Div Mol Med, Taichung, Taiwan

[2] Taipei Municipal Jen Ai Hosp, Dept Neurol Mol Med, Taipei, Taiwan

[3] Taipei City Psychiat Ctr, Taipei, Taiwan

[4] Taipei Med Coll, Grad Inst Biomed Technol, Taipei, Taiwan

来源：

NEUROLOGY | 1999年 / 53卷 / 03期

关键词：

D O I：

10.1212/WNL.53.3.642

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The alpha-2 macroglobulin five-nucleotide deletion (A2M-2) allele frequency was not significantly higher in the AD group than the control group (0.062 versus 0.101, p > 0.1). The odds ratio for AD in individuals with the A2M-2 allele was 0.582 (95% CI, 0.25 to 1.40). These results do not support the association between A2M-2 and AD in the Chinese population, although the allele frequency of A2M-2 is lower than that found in the Caucasian population. Therefore, A2M-2 might not be a significant risk factor of AD among Taiwan Chinese.

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页码：642 / 643

页数：2

相关论文

共 10 条

[1] Alpha-2 macroglobulin is genetically associated with Alzheimer disease [J].

Blacker, D ;

Wilcox, MA ;

Laird, NM ;

Rodes, L ;

Horvath, SM ;

Go, RCP ;

Perry, R ;

Watson, B ;

Bassett, SS ;

McInnis, MG ;

Albert, MS ;

Hyman, BT ;

Tanzi, RE .

NATURE GENETICS, 1998, 19 (04) :357-360

[2] Association of apolipoprotein E genotype and intronic polymorphism of the presenilin-1 gene with Alzheimer's disease in elderly Taiwan Chinese [J].

Hu, CJ ;

Sung, SM ;

Liu, HC ;

Chang, JG .

JOURNAL OF THE NEUROLOGICAL SCIENCES, 1998, 157 (02) :158-161

[3] Genetic association of the low-density lipoprotein receptor-related protein gene (LRP), an apolipoprotein E receptor, with late-onset Alzheimer's disease [J].

Kang, DE ;

Saitoh, T ;

Chen, X ;

Xia, Y ;

Masliah, E ;

Hansen, LA ;

Thomas, RG ;

Thal, LJ ;

Katzman, R .

NEUROLOGY, 1997, 49 (01) :56-61

[4] LDL RECEPTOR-RELATED PROTEIN, A MULTIFUNCTIONAL APOE RECEPTOR, BINDS SECRETED BETA-AMYLOID PRECURSOR PROTEIN AND MEDIATES ITS DEGRADATION [J].

KOUNNAS, MZ ;

MOIR, RD ;

REBECK, GW ;

BUSH, AI ;

ARGRAVES, WS ;

TANZI, RE ;

HYMAN, BT ;

STRICKLAND, DK .

CELL, 1995, 82 (02) :331-340

[5] Genetic association studies between dementia of the Alzheimer's type and three receptors for apolipoprotein E in a Caucasian population [J].

Lendon, CL ;

Talbot, CJ ;

Craddock, NJ ;

Han, SW ;

Wragg, M ;

Morris, JC ;

Goate, AM .

NEUROSCIENCE LETTERS, 1997, 222 (03) :187-190

[6] Neurogenetics - New gene tied to common form of Alzheimer's [J].

Marx, J .

SCIENCE, 1998, 281 (5376) :507-+

[7] A DELETION POLYMORPHISM IN THE HUMAN ALPHA-2-MACROGLOBULIN (A2M) GENE [J].

MATTHIJS, G ;

MARYNEN, P .

NUCLEIC ACIDS RESEARCH, 1991, 19 (18) :5102-5102

[8]

Narita M, 1997, J NEUROCHEM, V69, P1904

[9] Degradation of amyloid beta-protein by a serine protease-alpha(2)-macroglobulin complex [J].

Qiu, WQ ;

Borth, W ;

Ye, Z ;

Haass, C ;

Teplow, DB ;

Selkoe, DJ .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (14) :8443-8451

[10] MULTIPLE, DIVERSE SENILE PLAQUE-ASSOCIATED PROTEINS ARE LIGANDS OF AN APOLIPOPROTEIN-E RECEPTOR, THE ALPHA(2)-MACROGLOBULIN RECEPTOR LOW-DENSITY-LIPOPROTEIN RECEPTOR-RELATED PROTEIN [J].

REBECK, GW ;

HARR, SD ;

STRICKLAND, DK ;

HYMAN, BT .

ANNALS OF NEUROLOGY, 1995, 37 (02) :211-217