Intermolecular Aminotrifluoromethylation of Alkenes by Visible-Light-Driven Photoredox Catalysis

被引：279

作者：

Yasu, Yusuke ^{[1
]}

Koike, Takashi ^{[1
]}

Akita, Munetaka ^{[1
]}

机构：

[1] Tokyo Inst Technol, Chem Resources Lab, Midori Ku, Yokohama, Kanagawa 2268503, Japan

来源：

ORGANIC LETTERS | 2013年 / 15卷 / 09期

关键词：

ELECTROPHILIC TRIFLUOROMETHYLATION; ORGANIC-SYNTHESIS; OXYTRIFLUOROMETHYLATION; HYDROTRIFLUOROMETHYLATION; DIFUNCTIONALIZATION; PHOTOCHEMISTRY; PHOTOCATALYSIS; PHOTOPHYSICS; HETEROCYCLES; ALDEHYDES;

D O I：

10.1021/ol4006272

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Intermolecular aminotrifluoromethylation of alkenes catalyzed by [Ru(bpy)(3)](2+) under visible light irradiation has been explored. The present photocatalytic protocol achieves highly efficient and regioselective difunctionalization of C=C bonds, leading to a variety of beta-trifluoromethylamines. The reaction is applied to "late-stage aminotrifluoromethylation" of steroid and amino acid scaffolds.

引用

页码：2136 / 2139

页数：4

共 52 条

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