共 40 条
Syndapin I is the phosphorylation-regulated dynamin I partner in synaptic vesicle endocytosis
被引:172
作者:

Anggono, Victor
论文数: 0 引用数: 0
h-index: 0
机构: Childrens Med Res Inst, Cell Signalling Unit, Wentworthville, NSW 2145, Australia

Smillie, Karen J.
论文数: 0 引用数: 0
h-index: 0
机构: Childrens Med Res Inst, Cell Signalling Unit, Wentworthville, NSW 2145, Australia

Graham, Mark E.
论文数: 0 引用数: 0
h-index: 0
机构: Childrens Med Res Inst, Cell Signalling Unit, Wentworthville, NSW 2145, Australia

Valova, Valentina A.
论文数: 0 引用数: 0
h-index: 0
机构: Childrens Med Res Inst, Cell Signalling Unit, Wentworthville, NSW 2145, Australia

Cousin, Michael A.
论文数: 0 引用数: 0
h-index: 0
机构: Childrens Med Res Inst, Cell Signalling Unit, Wentworthville, NSW 2145, Australia

Robinson, Phillip J.
论文数: 0 引用数: 0
h-index: 0
机构: Childrens Med Res Inst, Cell Signalling Unit, Wentworthville, NSW 2145, Australia
机构:
[1] Childrens Med Res Inst, Cell Signalling Unit, Wentworthville, NSW 2145, Australia
[2] Univ Edinburgh, Membrane Biol Grp, Ctr Integrat Physiol, Edinburgh EH8 9XD, Midlothian, Scotland
基金:
英国惠康基金;
关键词:
D O I:
10.1038/nn1695
中图分类号:
Q189 [神经科学];
学科分类号:
071006 ;
摘要:
Dynamin I is dephosphorylated at Ser-774 and Ser-778 during synaptic vesicle endocytosis (SVE) in nerve terminals. Phosphorylation was proposed to regulate the assembly of an endocytic protein complex with amphiphysin or endophilin. Instead, we found it recruits syndapin I for SVE and does not control amphiphysin or endophilin binding in rat synaptosomes. After depolarization, syndapin showed a calcineurin-mediated interaction with dynamin. A peptide mimicking the phosphorylation sites disrupted the dynamin-syndapin complex, not the dynamin-endophilin complex, arrested SVE and produced glutamate release fatigue after repetitive stimulation. Pseudophosphorylation of Ser-774 or Ser-778 inhibited syndapin binding without affecting amphiphysin recruitment. Site mutagenesis to alanine arrested SVE in cultured neurons. The effects of the sites were additive for syndapin I binding and SVE. Thus syndapin I is a central component of the endocytic protein complex for SVE via stimulus-dependent recruitment to dynamin I and has a key role in synaptic transmission.
引用
收藏
页码:752 / 760
页数:9
相关论文
共 40 条
- [21] Regulation of synaptojanin 1 by cyclin-dependent kinase 5 at synapses[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (02) : 546 - 551Lee, SY论文数: 0 引用数: 0 h-index: 0机构: Yale Univ, Sch Med, Dept Cell Biol, New Haven, CT 06510 USAWenk, MR论文数: 0 引用数: 0 h-index: 0机构: Yale Univ, Sch Med, Dept Cell Biol, New Haven, CT 06510 USAKim, Y论文数: 0 引用数: 0 h-index: 0机构: Yale Univ, Sch Med, Dept Cell Biol, New Haven, CT 06510 USANaim, AC论文数: 0 引用数: 0 h-index: 0机构: Yale Univ, Sch Med, Dept Cell Biol, New Haven, CT 06510 USADe Camilli, P论文数: 0 引用数: 0 h-index: 0机构: Yale Univ, Sch Med, Dept Cell Biol, New Haven, CT 06510 USA
- [22] CALCINEURIN INHIBITION OF DYNAMIN-I GTPASE ACTIVITY COUPLED TO NERVE-TERMINAL DEPOLARIZATION[J]. SCIENCE, 1994, 265 (5174) : 970 - 973LIU, JP论文数: 0 引用数: 0 h-index: 0机构: UNIV NEWCASTLE,NEUROSCI GRP,NEWCASTLE,NSW 2308,AUSTRALIA UNIV NEWCASTLE,NEUROSCI GRP,NEWCASTLE,NSW 2308,AUSTRALIASIM, ATR论文数: 0 引用数: 0 h-index: 0机构: UNIV NEWCASTLE,NEUROSCI GRP,NEWCASTLE,NSW 2308,AUSTRALIA UNIV NEWCASTLE,NEUROSCI GRP,NEWCASTLE,NSW 2308,AUSTRALIAROBINSON, PJ论文数: 0 引用数: 0 h-index: 0机构: UNIV NEWCASTLE,NEUROSCI GRP,NEWCASTLE,NSW 2308,AUSTRALIA UNIV NEWCASTLE,NEUROSCI GRP,NEWCASTLE,NSW 2308,AUSTRALIA
- [23] Regulated interactions between dynamin and the actin-binding protein cortactin modulate cell shape[J]. JOURNAL OF CELL BIOLOGY, 2000, 151 (01) : 187 - 198McNiven, MA论文数: 0 引用数: 0 h-index: 0机构: Mayo Clin & Mayo Fdn, Dept Biochem & Mol Biol, Rochester, MN 55905 USAKim, L论文数: 0 引用数: 0 h-index: 0机构: Mayo Clin & Mayo Fdn, Dept Biochem & Mol Biol, Rochester, MN 55905 USAKrueger, EW论文数: 0 引用数: 0 h-index: 0机构: Mayo Clin & Mayo Fdn, Dept Biochem & Mol Biol, Rochester, MN 55905 USAOrth, JD论文数: 0 引用数: 0 h-index: 0机构: Mayo Clin & Mayo Fdn, Dept Biochem & Mol Biol, Rochester, MN 55905 USACao, H论文数: 0 引用数: 0 h-index: 0机构: Mayo Clin & Mayo Fdn, Dept Biochem & Mol Biol, Rochester, MN 55905 USAWong, TW论文数: 0 引用数: 0 h-index: 0机构: Mayo Clin & Mayo Fdn, Dept Biochem & Mol Biol, Rochester, MN 55905 USA
- [24] Visualizing secretion and synaptic transmission with pH-sensitive green fluorescent proteins[J]. NATURE, 1998, 394 (6689) : 192 - 195Miesenböck, G论文数: 0 引用数: 0 h-index: 0机构: Mem Sloan Kettering Canc Ctr, Cellular Biochem & Biophys Program, New York, NY 10021 USA Mem Sloan Kettering Canc Ctr, Cellular Biochem & Biophys Program, New York, NY 10021 USADe Angelis, DA论文数: 0 引用数: 0 h-index: 0机构: Mem Sloan Kettering Canc Ctr, Cellular Biochem & Biophys Program, New York, NY 10021 USA Mem Sloan Kettering Canc Ctr, Cellular Biochem & Biophys Program, New York, NY 10021 USARothman, JE论文数: 0 引用数: 0 h-index: 0机构: Mem Sloan Kettering Canc Ctr, Cellular Biochem & Biophys Program, New York, NY 10021 USA Mem Sloan Kettering Canc Ctr, Cellular Biochem & Biophys Program, New York, NY 10021 USA
- [25] The large GTPase dynamin regulates actin comet formation and movement in living cells[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (01) : 167 - 172Orth, JD论文数: 0 引用数: 0 h-index: 0机构: Mayo Clin, Dept Biochem & Mol Biol, Rochester, MN 55905 USA Mayo Clin, Dept Biochem & Mol Biol, Rochester, MN 55905 USAKrueger, EW论文数: 0 引用数: 0 h-index: 0机构: Mayo Clin, Dept Biochem & Mol Biol, Rochester, MN 55905 USA Mayo Clin, Dept Biochem & Mol Biol, Rochester, MN 55905 USACao, H论文数: 0 引用数: 0 h-index: 0机构: Mayo Clin, Dept Biochem & Mol Biol, Rochester, MN 55905 USA Mayo Clin, Dept Biochem & Mol Biol, Rochester, MN 55905 USAMcNiven, MA论文数: 0 引用数: 0 h-index: 0机构: Mayo Clin, Dept Biochem & Mol Biol, Rochester, MN 55905 USA Mayo Clin, Dept Biochem & Mol Biol, Rochester, MN 55905 USA
- [26] BAR domains as sensors of membrane curvature: The amphiphysin BAR structure[J]. SCIENCE, 2004, 303 (5657) : 495 - 499Peter, BJ论文数: 0 引用数: 0 h-index: 0机构: MRC, Mol Biol Lab, Cambridge CB2 2QH, England MRC, Mol Biol Lab, Cambridge CB2 2QH, EnglandKent, HM论文数: 0 引用数: 0 h-index: 0机构: MRC, Mol Biol Lab, Cambridge CB2 2QH, England MRC, Mol Biol Lab, Cambridge CB2 2QH, EnglandMills, IG论文数: 0 引用数: 0 h-index: 0机构: MRC, Mol Biol Lab, Cambridge CB2 2QH, England MRC, Mol Biol Lab, Cambridge CB2 2QH, EnglandVallis, Y论文数: 0 引用数: 0 h-index: 0机构: MRC, Mol Biol Lab, Cambridge CB2 2QH, England MRC, Mol Biol Lab, Cambridge CB2 2QH, EnglandButler, PJG论文数: 0 引用数: 0 h-index: 0机构: MRC, Mol Biol Lab, Cambridge CB2 2QH, England MRC, Mol Biol Lab, Cambridge CB2 2QH, EnglandEvans, PR论文数: 0 引用数: 0 h-index: 0机构: MRC, Mol Biol Lab, Cambridge CB2 2QH, England MRC, Mol Biol Lab, Cambridge CB2 2QH, EnglandMcMahon, HT论文数: 0 引用数: 0 h-index: 0机构: MRC, Mol Biol Lab, Cambridge CB2 2QH, England MRC, Mol Biol Lab, Cambridge CB2 2QH, England
- [27] Syndapin I, a synaptic dynamin binding protein that associates with the neural Wiskott-Aldrich syndrome protein[J]. MOLECULAR BIOLOGY OF THE CELL, 1999, 10 (02) : 501 - 513Qualmann, B论文数: 0 引用数: 0 h-index: 0机构: Univ Calif San Francisco, Dept Biochem & Biophys, San Francisco, CA 94143 USARoos, J论文数: 0 引用数: 0 h-index: 0机构: Univ Calif San Francisco, Dept Biochem & Biophys, San Francisco, CA 94143 USADiGregorio, PJ论文数: 0 引用数: 0 h-index: 0机构: Univ Calif San Francisco, Dept Biochem & Biophys, San Francisco, CA 94143 USAKelly, RB论文数: 0 引用数: 0 h-index: 0机构: Univ Calif San Francisco, Dept Biochem & Biophys, San Francisco, CA 94143 USA Univ Calif San Francisco, Dept Biochem & Biophys, San Francisco, CA 94143 USA
- [28] The SH3p4/Sh3p8/SH3p13 protein family: Binding partners for synaptojanin and dynamin via a Grb2-like Src homology 3 domain[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (16) : 8569 - 8574Ringstad, N论文数: 0 引用数: 0 h-index: 0机构: YALE UNIV,SCH MED,HOWARD HUGHES MED INST,NEW HAVEN,CT 06510 YALE UNIV,SCH MED,HOWARD HUGHES MED INST,NEW HAVEN,CT 06510Nemoto, Y论文数: 0 引用数: 0 h-index: 0机构: YALE UNIV,SCH MED,HOWARD HUGHES MED INST,NEW HAVEN,CT 06510 YALE UNIV,SCH MED,HOWARD HUGHES MED INST,NEW HAVEN,CT 06510DeCamilli, P论文数: 0 引用数: 0 h-index: 0机构: YALE UNIV,SCH MED,HOWARD HUGHES MED INST,NEW HAVEN,CT 06510 YALE UNIV,SCH MED,HOWARD HUGHES MED INST,NEW HAVEN,CT 06510
- [29] DYNAMIN GTPASE REGULATED BY PROTEIN-KINASE-C PHOSPHORYLATION IN NERVE-TERMINALS[J]. NATURE, 1993, 365 (6442) : 163 - 166ROBINSON, PJ论文数: 0 引用数: 0 h-index: 0机构: UNIV TEXAS, SW MED CTR, DEPT MOLEC GENET, 5323 HARRY HINES BLVD, DALLAS, TX 75235 USASONTAG, JM论文数: 0 引用数: 0 h-index: 0机构: UNIV TEXAS, SW MED CTR, DEPT MOLEC GENET, 5323 HARRY HINES BLVD, DALLAS, TX 75235 USALIU, JP论文数: 0 引用数: 0 h-index: 0机构: UNIV TEXAS, SW MED CTR, DEPT MOLEC GENET, 5323 HARRY HINES BLVD, DALLAS, TX 75235 USAFYKSE, EM论文数: 0 引用数: 0 h-index: 0机构: UNIV TEXAS, SW MED CTR, DEPT MOLEC GENET, 5323 HARRY HINES BLVD, DALLAS, TX 75235 USASLAUGHTER, C论文数: 0 引用数: 0 h-index: 0机构: UNIV TEXAS, SW MED CTR, DEPT MOLEC GENET, 5323 HARRY HINES BLVD, DALLAS, TX 75235 USAMCMAHON, H论文数: 0 引用数: 0 h-index: 0机构: UNIV TEXAS, SW MED CTR, DEPT MOLEC GENET, 5323 HARRY HINES BLVD, DALLAS, TX 75235 USASUDHOF, TC论文数: 0 引用数: 0 h-index: 0机构: UNIV TEXAS, SW MED CTR, DEPT MOLEC GENET, 5323 HARRY HINES BLVD, DALLAS, TX 75235 USA
- [30] Actin has a molecular scaffolding, not propulsive, role in presynaptic function[J]. NATURE NEUROSCIENCE, 2003, 6 (02) : 127 - 135Sankaranarayanan, S论文数: 0 引用数: 0 h-index: 0机构: Cornell Univ, Weill Med Coll, Dept Biochem, New York, NY 10021 USA Cornell Univ, Weill Med Coll, Dept Biochem, New York, NY 10021 USAAtluri, PP论文数: 0 引用数: 0 h-index: 0机构: Cornell Univ, Weill Med Coll, Dept Biochem, New York, NY 10021 USA Cornell Univ, Weill Med Coll, Dept Biochem, New York, NY 10021 USARyan, TA论文数: 0 引用数: 0 h-index: 0机构: Cornell Univ, Weill Med Coll, Dept Biochem, New York, NY 10021 USA Cornell Univ, Weill Med Coll, Dept Biochem, New York, NY 10021 USA