Kinetic resolution of chiral auxiliaries with C-2-symmetry by lipase-catalyzed alcoholysis and aminolysis

被引：19

作者：

Mattson, A

Orrenius, C

Ohrner, N

Unelius, CR

Hult, K

Norin, T

机构：

[1] ROYAL INST TECHNOL,DEPT CHEM ORGAN CHEM,S-10044 STOCKHOLM,SWEDEN

[2] ROYAL INST TECHNOL,DEPT BIOCHEM & BIOTECHNOL,S-10044 STOCKHOLM,SWEDEN

来源：

ACTA CHEMICA SCANDINAVICA | 1996年 / 50卷 / 10期

关键词：

D O I：

10.3891/acta.chem.scand.50-0918

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Three cyclic diols, 1,2-cyclohexanediol (1), 1,3-cyclohexanediol (2), and 1,3-cyclopentanediol (3), two acyclic unsaturated diols, 1,5-hexadiene-3,4-diol (4) and 1,7-octadiyne-3,6-diol (5), and a cyclic diamine, 1,2-cyclohexanediamine (6), have been kinetically resolved in alcoholysis and aminolysis reactions, catalyzed by Candida antarctica component B lipase, using S-ethyl thiooctanoate or ethyl octanoate as acyl donors. Acceptable stereoselectivity was achieved in most cases.

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页码：918 / 921

页数：4

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