ATP, calcium and magnesium levels in platelets of patients with primary fibromyalgia

被引：32

作者：

Bazzichi, Laura ^{[2
]}

Giannaccini, Gino ^{[1
]}

Betti, Laura ^{[1
]}

Fabbrini, Laura ^{[1
]}

Schmid, Lara ^{[1
]}

Palego, Lionella ^{[1
]}

Glacomelli, Camillo ^{[1
]}

Rossi, Alessandra ^{[1
]}

Giusti, Laura ^{[1
]}

De Feo, Francesca ^{[2
]}

Giuliano, Tiziana ^{[2
]}

Mascia, Giovanni ^{[1
]}

Bombardier, Stefano ^{[2
]}

Lucacchini, Antonio ^{[1
]}

机构：

[1] Univ Pisa, Dept Psychiat Neurobiol Pharmacol & Biotechnol, I-56126 Pisa, Italy

[2] Univ Pisa, Div Rheumatol, Dept Internal Med, I-56126 Pisa, Italy

来源：

CLINICAL BIOCHEMISTRY | 2008年 / 41卷 / 13期

关键词：

ribromyalgia; platelets; adenosine triphosphate; calcium magnesium;

D O I：

10.1016/j.clinbiochem.2008.06.012

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Objectives: To evaluate the inracellular levels of the high energy adenosine triphosphate nucleotide ATP and essential divalent cations, calcium and magnesium, in platelets of patients affected by primary fibromyalgia syndrome (FMs). Design and method: Platelet ATP and cation concentrations were measured in 25 patients affected by FMs and 25 healthy volunteers through a chemiluminescent and a fluorimetric assay, respectively. Results: Significant lower ATP levels were observed inside platelets of FM patients (fmol ATP/plt: 0.0169 +/- 0.0012 vs. healthy controls, fmol ATP/plt: 0.0306 +/- 0.0023, mean +/- SEM) (***P<0.0001). A trend towards higher calcium concentrations (P=0.06) together with significant increased magnesium levels were also reported in platelets of patients by comparison with controls (P=0.02). Conclusions: This preliminary study suggests that distrubances in the homeostasis of platelet ATP metabolism-signaling and calcium-magnesium flows might have a relevance in the pathogenesis of FMs. (C) 2008 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.

引用

页码：1084 / 1090

页数：7

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