Worms take the 'phyto' out of "phytochelatins"

被引:34
作者
Vatamaniuk, OK [1 ]
Bucher, EA
Ward, JT
Rea, PA
机构
[1] Univ Penn, Inst Plant Sci, Dept Biol, Philadelphia, PA 19104 USA
[2] Univ Penn, Dept Cell & Dev Biol, Sch Med, Philadelphia, PA 19104 USA
关键词
D O I
10.1016/S0167-7799(01)01873-X
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Phytochelatin synthase is the enzyme responsible for the synthesis of heavy-metal-binding peptides (phytochelatins) from glutathione and related thiols. It has recently been determined that it is not only restricted to plants and some fungi, as was once thought, but also has an essential role in heavy-metal detoxification in the model nematode Caenorhabditis elegans. These findings and others that demonstrate phytochelatin synthase-coding sequences in the genomes of several other invertebrates, including pathogenic nematodes, schistosomes and roundworms, herald a new era in phytochelatin research, in which these novel post-translationally synthesized peptides will not only be investigated in the context of phytoremediation but also from a clinical parasitological standpoint.
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收藏
页码:61 / 64
页数:4
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