Regulated necrosis and its implications in toxicology

被引：36

作者：

Aki, Toshihiko ^{[1
]}

Funakoshi, Takeshi ^{[1
]}

Uemura, Koichi ^{[1
]}

机构：

[1] Tokyo Med & Dent Univ, Grad Sch Med & Dent Sci, Dept Forens Med, Tokyo, Japan

来源：

TOXICOLOGY | 2015年 / 333卷

关键词：

Cell death; Necrosis; Xenobiotics; APOPTOSIS-INDUCING-FACTOR; NONAPOPTOTIC-CELL-DEATH; NADH OXIDASE ACTIVITY; MIXED LINEAGE KINASE; DOMAIN-LIKE PROTEIN; POLY(ADP-RIBOSE) POLYMERASE; GLIOBLASTOMA CELLS; SMALL-MOLECULE; NLRP3; INFLAMMASOME; TUMOR SUPPRESSION;

D O I：

10.1016/j.tox.2015.04.003

中图分类号：

R9 [药学];

学科分类号：

100702 [药剂学];

摘要：

Recent research developments have revealed that caspase-dependent apoptosis is not the sole form of regulated cell death. Caspase-independent, but genetically regulated, forms of cell death include pyroptosis, necroptosis, parthanatos, and the recently discovered ferroptosis and autosis. Importantly, regulated necrosis can be modulated by small molecule inhibitors/activators, confirming the cell autonomous mechanism of these forms of cell death. The success of small molecule-mediated manipulation of regulated necrosis has produced great changes in the field of cell death research, and has also brought about significant changes in the fields of pharmacology as well as toxicology. In this review, we intend to summarize the modes of regulated cell death other than apoptosis, and discuss their implications in toxicology. (C) 2015 Elsevier Ireland Ltd. All rights reserved.

引用

页码：118 / 126

页数：9

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