共 43 条
Activation of the MAPK Module from Different Spatial Locations Generates Distinct System Outputs
被引:67
作者:

Inder, Kerry
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机构:
Univ Queensland, Inst Mol Biosci, Brisbane, Qld 4072, Australia Univ Queensland, Inst Mol Biosci, Brisbane, Qld 4072, Australia

Harding, Angus
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机构:
Univ Queensland, Queensland Brain Inst, Brisbane, Qld 4072, Australia Univ Queensland, Inst Mol Biosci, Brisbane, Qld 4072, Australia

Plowman, Sarah J.
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h-index: 0
机构:
Univ Queensland, Inst Mol Biosci, Brisbane, Qld 4072, Australia Univ Queensland, Inst Mol Biosci, Brisbane, Qld 4072, Australia

Philips, Mark R.
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机构:
NYU, Sch Med, New York, NY 10016 USA Univ Queensland, Inst Mol Biosci, Brisbane, Qld 4072, Australia

Parton, Robert G.
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机构:
Univ Queensland, Inst Mol Biosci, Brisbane, Qld 4072, Australia
Univ Queensland, Ctr Microscopy & Microanal, Brisbane, Qld 4072, Australia Univ Queensland, Inst Mol Biosci, Brisbane, Qld 4072, Australia

Hancock, John F.
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机构:
Univ Queensland, Inst Mol Biosci, Brisbane, Qld 4072, Australia Univ Queensland, Inst Mol Biosci, Brisbane, Qld 4072, Australia
机构:
[1] Univ Queensland, Inst Mol Biosci, Brisbane, Qld 4072, Australia
[2] Univ Queensland, Queensland Brain Inst, Brisbane, Qld 4072, Australia
[3] NYU, Sch Med, New York, NY 10016 USA
[4] Univ Queensland, Ctr Microscopy & Microanal, Brisbane, Qld 4072, Australia
基金:
美国国家卫生研究院;
澳大利亚研究理事会;
英国医学研究理事会;
关键词:
D O I:
10.1091/mbc.E08-04-0407
中图分类号:
Q2 [细胞生物学];
学科分类号:
071009 ;
090102 ;
摘要:
The Ras/Raf/MEK/ERK (MAPK) pathway directs multiple cell fate decisions within a single cell. How different system outputs are generated is unknown. Here we explore whether activating the MAPK module from different membrane environments can rewire system output. We identify two classes of nanoscale environment within the plasma membrane. The first, which corresponds to nanoclusters occupied by GTP-loaded H-, N- or K-Ras, supports Raf activation and amplifies low Raf kinase input to generate a digital ERKpp output. The second class, which corresponds to nanoclusters occupied by GDP-loaded Ras, cannot activate Raf and therefore does not activate the MAPK module, illustrating how lateral segregation on plasma membrane influences signal output. The MAPK module is activated at the Golgi, but in striking contrast to the plasma membrane, ERKpp output is analog. Different modes of Raf activation precisely correlate with these different ERKpp system outputs. Intriguingly, the Golgi contains two distinct membrane environments that generate ERKpp, but only one is competent to drive PC12 cell differentiation. The MAPK module is not activated from the ER. Taken together these data clearly demonstrate that the different nanoscale environments available to Ras generate distinct circuit configurations for the MAPK module, bestowing cells with a simple mechanism to generate multiple system outputs from a single cascade.
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页码:4776 / 4784
页数:9
相关论文
共 43 条
[1]
A novel switch region regulates H-ras membrane orientation and signal output
[J].
Abankwa, Daniel
;
Hanzal-Bayer, Michael
;
Ariotti, Nicolas
;
Plowman, Sarah J.
;
Gorfe, Alemayehu A.
;
Parton, Robert G.
;
McCammon, J. Andrew
;
Hancock, John F.
.
EMBO JOURNAL,
2008, 27 (05)
:727-735

Abankwa, Daniel
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Queensland, Inst Mol Biosci, Brisbane, Qld 4072, Australia Univ Queensland, Inst Mol Biosci, Brisbane, Qld 4072, Australia

Hanzal-Bayer, Michael
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Queensland, Inst Mol Biosci, Brisbane, Qld 4072, Australia Univ Queensland, Inst Mol Biosci, Brisbane, Qld 4072, Australia

Ariotti, Nicolas
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Queensland, Inst Mol Biosci, Brisbane, Qld 4072, Australia Univ Queensland, Inst Mol Biosci, Brisbane, Qld 4072, Australia

Plowman, Sarah J.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Queensland, Inst Mol Biosci, Brisbane, Qld 4072, Australia Univ Queensland, Inst Mol Biosci, Brisbane, Qld 4072, Australia

Gorfe, Alemayehu A.
论文数: 0 引用数: 0
h-index: 0
机构:
Ctr Theoret Biol Phys, Dept Chem & Biochem, La Jolla, CA USA Univ Queensland, Inst Mol Biosci, Brisbane, Qld 4072, Australia

Parton, Robert G.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Queensland, Inst Mol Biosci, Brisbane, Qld 4072, Australia
Univ Queensland, Ctr Microscopy & Microanal, Brisbane, Qld 4072, Australia Univ Queensland, Inst Mol Biosci, Brisbane, Qld 4072, Australia

McCammon, J. Andrew
论文数: 0 引用数: 0
h-index: 0
机构:
Ctr Theoret Biol Phys, Dept Chem & Biochem, La Jolla, CA USA
Univ Calif San Diego, Dept Pharmacol, Howard Hughes Med Inst, La Jolla, CA 92093 USA Univ Queensland, Inst Mol Biosci, Brisbane, Qld 4072, Australia

Hancock, John F.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Queensland, Inst Mol Biosci, Brisbane, Qld 4072, Australia Univ Queensland, Inst Mol Biosci, Brisbane, Qld 4072, Australia
[2]
H-ras but not K-ras traffics to the plasma membrane through the exocytic pathway
[J].
Apolloni, A
;
Prior, IA
;
Lindsay, M
;
Parton, RG
;
Hancock, JF
.
MOLECULAR AND CELLULAR BIOLOGY,
2000, 20 (07)
:2475-2487

Apolloni, A
论文数: 0 引用数: 0
h-index: 0
机构: Univ Queensland, Sch Med, Dept Pathol, Queensland Canc Fund Lab Expt Oncol, Brisbane, Qld 4069, Australia

Prior, IA
论文数: 0 引用数: 0
h-index: 0
机构: Univ Queensland, Sch Med, Dept Pathol, Queensland Canc Fund Lab Expt Oncol, Brisbane, Qld 4069, Australia

Lindsay, M
论文数: 0 引用数: 0
h-index: 0
机构: Univ Queensland, Sch Med, Dept Pathol, Queensland Canc Fund Lab Expt Oncol, Brisbane, Qld 4069, Australia

Parton, RG
论文数: 0 引用数: 0
h-index: 0
机构: Univ Queensland, Sch Med, Dept Pathol, Queensland Canc Fund Lab Expt Oncol, Brisbane, Qld 4069, Australia

Hancock, JF
论文数: 0 引用数: 0
h-index: 0
机构: Univ Queensland, Sch Med, Dept Pathol, Queensland Canc Fund Lab Expt Oncol, Brisbane, Qld 4069, Australia
[3]
Phospholipase Cγ activates Ras on the Golgi apparatus by means of RasGRP1
[J].
Bivona, TG
;
Perez de Castro, I
;
Ahearn, IM
;
Grana, TM
;
Chiu, VK
;
Lockyer, PJ
;
Cullen, PJ
;
Pellicer, A
;
Cox, AD
;
Philips, MR
.
NATURE,
2003, 424 (6949)
:694-698

Bivona, TG
论文数: 0 引用数: 0
h-index: 0
机构: NYU, Sch Med, Dept Med, New York, NY 10016 USA

Perez de Castro, I
论文数: 0 引用数: 0
h-index: 0
机构: NYU, Sch Med, Dept Med, New York, NY 10016 USA

Ahearn, IM
论文数: 0 引用数: 0
h-index: 0
机构: NYU, Sch Med, Dept Med, New York, NY 10016 USA

Grana, TM
论文数: 0 引用数: 0
h-index: 0
机构: NYU, Sch Med, Dept Med, New York, NY 10016 USA

Chiu, VK
论文数: 0 引用数: 0
h-index: 0
机构: NYU, Sch Med, Dept Med, New York, NY 10016 USA

Lockyer, PJ
论文数: 0 引用数: 0
h-index: 0
机构: NYU, Sch Med, Dept Med, New York, NY 10016 USA

Cullen, PJ
论文数: 0 引用数: 0
h-index: 0
机构: NYU, Sch Med, Dept Med, New York, NY 10016 USA

Pellicer, A
论文数: 0 引用数: 0
h-index: 0
机构: NYU, Sch Med, Dept Med, New York, NY 10016 USA

Cox, AD
论文数: 0 引用数: 0
h-index: 0
机构: NYU, Sch Med, Dept Med, New York, NY 10016 USA

Philips, MR
论文数: 0 引用数: 0
h-index: 0
机构: NYU, Sch Med, Dept Med, New York, NY 10016 USA
[4]
Nuclear translocation of p42/p44 mitogen-activated protein kinase is required for growth factor-induced gene expression and cell cycle entry
[J].
Brunet, A
;
Roux, D
;
Lenormand, P
;
Dowd, S
;
Keyse, S
;
Pouysségur, J
.
EMBO JOURNAL,
1999, 18 (03)
:664-674

Brunet, A
论文数: 0 引用数: 0
h-index: 0
机构: Univ Nice, Ctr Biochim, CNRS, UMR 6543, F-06108 Nice, France

Roux, D
论文数: 0 引用数: 0
h-index: 0
机构: Univ Nice, Ctr Biochim, CNRS, UMR 6543, F-06108 Nice, France

Lenormand, P
论文数: 0 引用数: 0
h-index: 0
机构: Univ Nice, Ctr Biochim, CNRS, UMR 6543, F-06108 Nice, France

Dowd, S
论文数: 0 引用数: 0
h-index: 0
机构: Univ Nice, Ctr Biochim, CNRS, UMR 6543, F-06108 Nice, France

Keyse, S
论文数: 0 引用数: 0
h-index: 0
机构: Univ Nice, Ctr Biochim, CNRS, UMR 6543, F-06108 Nice, France

Pouysségur, J
论文数: 0 引用数: 0
h-index: 0
机构: Univ Nice, Ctr Biochim, CNRS, UMR 6543, F-06108 Nice, France
[5]
Ras signalling on the endoplasmic reticulum and the Golgi
[J].
Chiu, VK
;
Bivona, T
;
Hach, A
;
Sajous, JB
;
Silletti, J
;
Wiener, H
;
Johnson, RL
;
Cox, AD
;
Philips, MR
.
NATURE CELL BIOLOGY,
2002, 4 (05)
:343-350

Chiu, VK
论文数: 0 引用数: 0
h-index: 0
机构: NYU, Sch Med, Dept Med, New York, NY 10016 USA

Bivona, T
论文数: 0 引用数: 0
h-index: 0
机构: NYU, Sch Med, Dept Med, New York, NY 10016 USA

Hach, A
论文数: 0 引用数: 0
h-index: 0
机构: NYU, Sch Med, Dept Med, New York, NY 10016 USA

Sajous, JB
论文数: 0 引用数: 0
h-index: 0
机构: NYU, Sch Med, Dept Med, New York, NY 10016 USA

Silletti, J
论文数: 0 引用数: 0
h-index: 0
机构: NYU, Sch Med, Dept Med, New York, NY 10016 USA

Wiener, H
论文数: 0 引用数: 0
h-index: 0
机构: NYU, Sch Med, Dept Med, New York, NY 10016 USA

Johnson, RL
论文数: 0 引用数: 0
h-index: 0
机构: NYU, Sch Med, Dept Med, New York, NY 10016 USA

Cox, AD
论文数: 0 引用数: 0
h-index: 0
机构: NYU, Sch Med, Dept Med, New York, NY 10016 USA

Philips, MR
论文数: 0 引用数: 0
h-index: 0
机构: NYU, Sch Med, Dept Med, New York, NY 10016 USA
[6]
Endomembrane trafficking of Ras: The CAAX motif targets proteins to the ER and Golgi
[J].
Choy, E
;
Chiu, VK
;
Silletti, J
;
Feoktistov, M
;
Morimoto, T
;
Michaelson, D
;
Ivanov, IE
;
Philips, MR
.
CELL,
1999, 98 (01)
:69-80

Choy, E
论文数: 0 引用数: 0
h-index: 0
机构: NYU, Sch Med, Dept Med, New York, NY 10016 USA

Chiu, VK
论文数: 0 引用数: 0
h-index: 0
机构: NYU, Sch Med, Dept Med, New York, NY 10016 USA

Silletti, J
论文数: 0 引用数: 0
h-index: 0
机构: NYU, Sch Med, Dept Med, New York, NY 10016 USA

Feoktistov, M
论文数: 0 引用数: 0
h-index: 0
机构: NYU, Sch Med, Dept Med, New York, NY 10016 USA

Morimoto, T
论文数: 0 引用数: 0
h-index: 0
机构: NYU, Sch Med, Dept Med, New York, NY 10016 USA

Michaelson, D
论文数: 0 引用数: 0
h-index: 0
机构: NYU, Sch Med, Dept Med, New York, NY 10016 USA

Ivanov, IE
论文数: 0 引用数: 0
h-index: 0
机构: NYU, Sch Med, Dept Med, New York, NY 10016 USA

Philips, MR
论文数: 0 引用数: 0
h-index: 0
机构:
NYU, Sch Med, Dept Med, New York, NY 10016 USA NYU, Sch Med, Dept Med, New York, NY 10016 USA
[7]
Thymic selection threshold defined by compartmentalization of Ras/MAPK signalling
[J].
Daniels, Mark A.
;
Teixeiro, Emma
;
Gill, Jason
;
Hausmann, Barbara
;
Roubaty, Dominique
;
Holmberg, Kaisa
;
Werlen, Guy
;
Hollaender, Georg A.
;
Gascoigne, Nicholas R. J.
;
Palmer, Ed
.
NATURE,
2006, 444 (7120)
:724-729

Daniels, Mark A.
论文数: 0 引用数: 0
h-index: 0
机构: Univ Basel Hosp, Dept Res, Lab Transplantat Immunol & Nephrol, CH-4031 Basel, Switzerland

Teixeiro, Emma
论文数: 0 引用数: 0
h-index: 0
机构: Univ Basel Hosp, Dept Res, Lab Transplantat Immunol & Nephrol, CH-4031 Basel, Switzerland

Gill, Jason
论文数: 0 引用数: 0
h-index: 0
机构: Univ Basel Hosp, Dept Res, Lab Transplantat Immunol & Nephrol, CH-4031 Basel, Switzerland

Hausmann, Barbara
论文数: 0 引用数: 0
h-index: 0
机构: Univ Basel Hosp, Dept Res, Lab Transplantat Immunol & Nephrol, CH-4031 Basel, Switzerland

Roubaty, Dominique
论文数: 0 引用数: 0
h-index: 0
机构: Univ Basel Hosp, Dept Res, Lab Transplantat Immunol & Nephrol, CH-4031 Basel, Switzerland

Holmberg, Kaisa
论文数: 0 引用数: 0
h-index: 0
机构: Univ Basel Hosp, Dept Res, Lab Transplantat Immunol & Nephrol, CH-4031 Basel, Switzerland

Werlen, Guy
论文数: 0 引用数: 0
h-index: 0
机构: Univ Basel Hosp, Dept Res, Lab Transplantat Immunol & Nephrol, CH-4031 Basel, Switzerland

Hollaender, Georg A.
论文数: 0 引用数: 0
h-index: 0
机构: Univ Basel Hosp, Dept Res, Lab Transplantat Immunol & Nephrol, CH-4031 Basel, Switzerland

Gascoigne, Nicholas R. J.
论文数: 0 引用数: 0
h-index: 0
机构: Univ Basel Hosp, Dept Res, Lab Transplantat Immunol & Nephrol, CH-4031 Basel, Switzerland

Palmer, Ed
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Basel Hosp, Dept Res, Lab Transplantat Immunol & Nephrol, CH-4031 Basel, Switzerland Univ Basel Hosp, Dept Res, Lab Transplantat Immunol & Nephrol, CH-4031 Basel, Switzerland
[8]
Untying the regulation of the Raf-1 kinase
[J].
Dhillon, AS
;
Kolch, W
.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS,
2002, 404 (01)
:3-9

Dhillon, AS
论文数: 0 引用数: 0
h-index: 0
机构: Beatson Inst Canc Res, Canc Res UK Beatson Labs, Glasgow G61 1BD, Lanark, Scotland

论文数: 引用数:
h-index:
机构:
[9]
Phosphorylation of Raf-1 serine 338 serine 339 is an essential regulatory event for Ras-dependent activation and biological signaling
[J].
Diaz, B
;
Barnard, D
;
Filson, A
;
MacDonald, S
;
King, A
;
Marshall, M
.
MOLECULAR AND CELLULAR BIOLOGY,
1997, 17 (08)
:4509-4516

Diaz, B
论文数: 0 引用数: 0
h-index: 0
机构: INDIANA UNIV, SCH MED, DEPT MED, INDIANAPOLIS, IN 46202 USA

Barnard, D
论文数: 0 引用数: 0
h-index: 0
机构: INDIANA UNIV, SCH MED, DEPT MED, INDIANAPOLIS, IN 46202 USA

Filson, A
论文数: 0 引用数: 0
h-index: 0
机构: INDIANA UNIV, SCH MED, DEPT MED, INDIANAPOLIS, IN 46202 USA

MacDonald, S
论文数: 0 引用数: 0
h-index: 0
机构: INDIANA UNIV, SCH MED, DEPT MED, INDIANAPOLIS, IN 46202 USA

King, A
论文数: 0 引用数: 0
h-index: 0
机构: INDIANA UNIV, SCH MED, DEPT MED, INDIANAPOLIS, IN 46202 USA

Marshall, M
论文数: 0 引用数: 0
h-index: 0
机构: INDIANA UNIV, SCH MED, DEPT MED, INDIANAPOLIS, IN 46202 USA
[10]
Spatial regulation of Raf kinase signaling by RKTG
[J].
Feng, Lin
;
Xie, Xiaoduo
;
Ding, Qiurong
;
Luo, Xiaolin
;
He, Jing
;
Fan, Fengjuan
;
Liu, Weizhong
;
Wang, Zhenzhen
;
Chen, Yan
.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,
2007, 104 (36)
:14348-14353

Feng, Lin
论文数: 0 引用数: 0
h-index: 0
机构:
Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Grad Sch, Shanghai 200031, Peoples R China Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Grad Sch, Shanghai 200031, Peoples R China

Xie, Xiaoduo
论文数: 0 引用数: 0
h-index: 0
机构:
Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Grad Sch, Shanghai 200031, Peoples R China Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Grad Sch, Shanghai 200031, Peoples R China

Ding, Qiurong
论文数: 0 引用数: 0
h-index: 0
机构:
Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Grad Sch, Shanghai 200031, Peoples R China Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Grad Sch, Shanghai 200031, Peoples R China

Luo, Xiaolin
论文数: 0 引用数: 0
h-index: 0
机构:
Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Grad Sch, Shanghai 200031, Peoples R China Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Grad Sch, Shanghai 200031, Peoples R China

He, Jing
论文数: 0 引用数: 0
h-index: 0
机构:
Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Grad Sch, Shanghai 200031, Peoples R China Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Grad Sch, Shanghai 200031, Peoples R China

Fan, Fengjuan
论文数: 0 引用数: 0
h-index: 0
机构:
Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Grad Sch, Shanghai 200031, Peoples R China Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Grad Sch, Shanghai 200031, Peoples R China

Liu, Weizhong
论文数: 0 引用数: 0
h-index: 0
机构:
Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Grad Sch, Shanghai 200031, Peoples R China Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Grad Sch, Shanghai 200031, Peoples R China

Wang, Zhenzhen
论文数: 0 引用数: 0
h-index: 0
机构:
Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Grad Sch, Shanghai 200031, Peoples R China Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Grad Sch, Shanghai 200031, Peoples R China

Chen, Yan
论文数: 0 引用数: 0
h-index: 0
机构:
Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Grad Sch, Shanghai 200031, Peoples R China Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Grad Sch, Shanghai 200031, Peoples R China