Transcription, translation and fragile X syndrome

被引:106
作者
Garber, Kathryn
Smith, Karen T.
Reines, Danny
Warren, Stephen T.
机构
[1] Emory Univ, Dept Human Genet, Atlanta, GA 30322 USA
[2] Emory Univ, Dept Biochem, Rollins Res Ctr 4023, Atlanta, GA 30322 USA
关键词
D O I
10.1016/j.gde.2006.04.010
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
The fragile X mental retardation protein (FMRP) plays a role in the control of local protein synthesis in the dendrites. Loss of its production in fragile X syndrome is associated with transcriptional dysregulation of the gene. Recent work demonstrates that Sp1 and NRF1 transcriptionally control this gene. Other studies reveal how the microRNA pathway and signaling are related to FMRP function through the metabotropic glutamate receptor. These studies provide new insights through which we can better understand the inactivation of the FMR1 gene and, in turn, the consequence of FMRP loss.
引用
收藏
页码:270 / 275
页数:6
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