Cytotoxic human CD4+ T cells

被引:101
作者
de Berg, Pablo J. van [1 ,2 ]
van Leeuwen, Ester M. [3 ]
Ten Berge, Ineke J. [2 ]
van Lier, Rene [1 ]
机构
[1] AMC, Dept Expt Immunol, Amsterdam, Netherlands
[2] AMC, Renal Transplant Unit, Amsterdam, Netherlands
[3] Scripps Res Inst, Dept Immunol, La Jolla, CA 92037 USA
关键词
D O I
10.1016/j.coi.2008.03.007
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The induction of adaptive immune responses critically depends on helper signals provided by CD4(+) T cells. These signals not only license antigen presenting cells (APC) to activate naive CD8(+) T cells leading to the formation of vast numbers of cytotoxic T lymphocytes but also support the differentiation of B cells into immunoglobulin-secreting plasma cells. Next to these helper functions, a subpopulation of CD4(+) T cells can also directly function as effector cells by executing cytotoxicity in a peptide-specific and MHC class II-restricted manner. Cytotoxic CD4(+) T cells may function in combating pathogens but additionally their presence has been associated with autoimmune disease and vascular damage. On the contrary, the induction of cytotoxic CD4(+) T cells may be a future target for vaccine strategies.
引用
收藏
页码:339 / 343
页数:5
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