Defensins of vertebrate animals

被引：584

作者：

Lehrer, RI

Ganz, T

机构：

[1] Univ Calif Los Angeles, Inst Mol Biol, Dept Med, Hlth Sci Ctr, Los Angeles, CA 90095 USA

[2] Univ Calif Los Angeles, Dept Pathol, Hlth Sci Ctr, Los Angeles, CA 90095 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 2002年 / 14卷 / 01期

关键词：

D O I：

10.1016/S0952-7915(01)00303-X

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

During the past year, novel beta-defensins of mice and men have been identified, together with a novel defensin subfamily (the circular or 'theta' minidefensins) in primates. Insight into the evolution of defensins has been obtained from structural studies, and several mechanisms related to microbial resistance to defensins have been delineated, There is now convincing evidence that defensins augment adaptive immune responses.

引用

页码：96 / 102

页数：7

共 53 条

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