Inhibition of hBD-3, but not hBD-1 and hBD-2, mRNA expression by corticosteroids

被引：57

作者：

Duits, LA ^{[1
]}

Rademaker, M

Ravensbergen, B

van Sterkenburg, MAJA

van Strijen, E

Hiemstra, PS

Nibbering, PH

机构：

[1] Leiden Univ, Med Ctr, Dept Infect Dis, NL-2300 RC Leiden, Netherlands

[2] Leiden Univ, Med Ctr, Dept Pulmonol, NL-2300 RC Leiden, Netherlands

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2001年 / 280卷 / 02期

关键词：

beta-defensins; corticosteroids; bronchial epithelial cells; mononuclear phagocytes;

D O I：

10.1006/bbrc.2000.4157

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Intensive use of corticosteroids may be accompanied by increased susceptibility to infections; hence, we investigated the effects of dexamethasone on the expression of antimicrobial peptides, termed human beta -defensins (hBD), by cultured bronchial epithelial cells and mononuclear phagocytes. The results revealed that dexamethasone inhibited the (stimulated) expression of mRNA for hBD-3, but not hBD-1 and hBD-2 by these epithelial cells. Dexamethasone did not affect the (stimulated) mRNA expression of hBD-1 and hBD-2 by mononuclear phagocytes, whereas these cells did not express hBD-3 mRNA. (C) 2001 Academic Press.

引用

页码：522 / 525

页数：4

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