Dual and Beneficial Roles of Macrophages During Skeletal Muscle Regeneration

被引：202

作者：

Chazaud, Benedicte ^{[1
,2
]}

Brigitte, Madly ^{[3
,4
]}

Yacoub-Youssef, Houda ^{[2
]}

Arnold, Ludovic ^{[5
]}

Gherardi, Romain ^{[3
,4
]}

Sonnet, Corinne ^{[6
]}

Lafuste, Peggy ^{[3
,4
]}

Chretien, Fabrice ^{[3
,4
]}

机构：

[1] Inst Cochin Genet Mol, CNRS, INSERM, U567,UMR 8104,Dept Genet & Dev, F-75014 Paris, France

[2] Univ Paris 05, Paris, France

[3] INSERM, U841, Equipe 10, F-75654 Paris 13, France

[4] Univ Paris 12, Creteil, France

[5] Inst Pasteur, Paris, France

[6] Baylor Coll Med, Ctr Cell & Gene Therapy, Houston, TX 77030 USA

来源：

EXERCISE AND SPORT SCIENCES REVIEWS | 2009年 / 37卷 / 01期

关键词：

myogenic cells; macrophage activation; tissue repair; inflammation; phagocytosis; SATELLITE CELLS; INFLAMMATORY RESPONSES; COX-2; PATHWAY; MONOCYTE; SUBPOPULATIONS; TGF-BETA-1; APOPTOSIS; SUPPORT; GROWTH; INJURY;

D O I：

10.1097/JES.0b013e318190ebdb

中图分类号：

Q4 [生理学];

学科分类号：

071003 [生理学];

摘要：

CHAZAUD, B., M. BRIGITTE, H. YACOUB-YOUSSEF, L. ARNOLD, R. GHERARDI, C. SONNET, P. LAFUSTE, and F. CHRETIEN. Dual and beneficial roles of macrophages during skeletal muscle regeneration. Exerc. Sport Sci. Rev., Vol. 37, No. 1, pp. 18-22, 2009. Macrophages are necessary for skeletal muscle regeneration after injury. Muscle recruits inflammatory monocytes/macrophages that switch toward an anti-inflammatory profile upon phagocytosis of debris. In vitro, proinflammatory macrophages stimulate myoblast proliferation, whereas anti-inflammatory macrophages stimulate their differentiation. Thus, macrophages are involved in both phases of skeletal muscle regeneration: first, inflammation and cleansing of necrosis, and then myogenic differentiation and tissue repair.

引用

页码：18 / 22

页数：5

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