Microsatellite instability and DNA mismatch repair in human cancer

被引：86

作者：

Karran, P

机构：

[1] Imperial Cancer Research Fund, Clare Hall Laboratories, South Mimms, Hertfordshire

来源：

SEMINARS IN CANCER BIOLOGY | 1996年 / 7卷 / 01期

关键词：

DNA repair; mutator phenotype; HNPCC;

D O I：

10.1006/scbi.1996.0003

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A form of genome instability in human tumours is associated with defects in a DNA mismatch repair pathway that normally corrects replication errors. The instability is observed as highly polymorphic mono- and dinucleotide microsatellites. Alterations in microsatellite length are due to accumulated frameshift mutations that arise because of uncorrected misalignments between template and daughter DNA strands during replication. Loss of mismatch repair is associated with some familial cancers, occurs at an early stage in tumour development and confers a general mutator phenotype. The latter may accelerate the accumulation of mutations in critical target genes during progression to malignancy. Biochemical analysis is providing insights into the mechanisms of mismatch repair.

引用

收藏

页码：15 / 24

页数：10

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