Who's in charge here? Regulating cell cycle regulators

被引：13

作者：

Bowers, Lisa M. ^{[1
]}

Shapland, Elaine B. ^{[1
]}

Ryan, Kathleen R. ^{[1
]}

机构：

[1] Univ Calif Berkeley, Dept Plant & Microbial Biol, Berkeley, CA 94720 USA

来源：

CURRENT OPINION IN MICROBIOLOGY | 2008年 / 11卷 / 06期

关键词：

D O I：

10.1016/j.mib.2008.09.019

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Recent studies have illuminated key features of the transcriptional and signal transduction networks governing the cell division cycle of Caulobacter crescentus. These mechanisms generate oscillations in the activity of CtrA, a key regulator of DNA replication and transcription of cell cycle regulated genes. ctrA transcription is itself regulated as part of a cascade of transcriptional regulators, each of which drives the synthesis of proteins needed at different stages of the cell cycle. The CtrA protein is post-transcriptionally regulated by an extended network of two-component signaling proteins and by proteolysis. Proteins within these pathways are localized at opposite ends of the cell to generate two progenies in different stages of the cell cycle upon cell division.

引用

页码：547 / 552

页数：6

共 49 条

[41] ATP ACTIVATES DNAA PROTEIN IN INITIATING REPLICATION OF PLASMIDS BEARING THE ORIGIN OF THE ESCHERICHIA-COLI CHROMOSOME [J].

SEKIMIZU, K ;

BRAMHILL, D ;

KORNBERG, A .

CELL, 1987, 50 (02) :259-265

[42] Architecture and inherent robustness of a bacterial cell-cycle control system [J].

Shen, Xiling ;

Collier, Justine ;

Dill, David ;

Shapiro, Lucy ;

Horowitz, Mark ;

McAdams, Harley H. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (32) :11340-11345

[43] Tightly regulated and heritable division control in single bacterial cells [J].

Siegal-Gaskins, Dan ;

Crosson, Sean .

BIOPHYSICAL JOURNAL, 2008, 95 (04) :2063-2072

[44] Positive feedback of G1 cyclins ensures coherent cell cycle entry [J].

Skotheim, Jan M. ;

Di Talia, Stefano ;

Siggia, Eric D. ;

Cross, Frederick R. .

NATURE, 2008, 454 (7202) :291-U12

[45] Identification of a localization factor for the polar positioning of bacterial structural and regulatory proteins [J].

Viollier, PH ;

Sternheim, N ;

Shapiro, L .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (21) :13831-13836

[46] Differential localization of two histidine kinases controlling bacterial cell differentiation [J].

Wheeler, RT ;

Shapiro, L .

MOLECULAR CELL, 1999, 4 (05) :683-694

[47] Caulobacter Lon protease has a critical role in cell-cycle control of DNA methylation [J].

Wright, R ;

Stephens, C ;

Zweiger, G ;

Shapiro, L ;

Alley, MRK .

GENES & DEVELOPMENT, 1996, 10 (12) :1532-1542

[48] An essential, multicomponent signal transduction pathway required for cell cycle regulation in Caulobacter [J].

Wu, JG ;

Ohta, N ;

Newton, A .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (04) :1443-1448

[49] A CAULOBACTER DNA METHYLTRANSFERASE THAT FUNCTIONS ONLY IN THE PREDIVISIONAL CELL [J].

ZWEIGER, G ;

MARCYNSKI, G ;

SHAPIRO, L .

JOURNAL OF MOLECULAR BIOLOGY, 1994, 235 (02) :472-485

← 1 2 3 4 5 →