MicroRNAs in cardiovascular disease: from pathogenesis to prevention and treatment

被引：321

作者：

Quiat, Daniel ^{[1
]}

Olson, Eric N. ^{[1
]}

机构：

[1] Univ Texas SW Med Ctr Dallas, Dept Mol Biol, Dallas, TX 75390 USA

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2013年 / 123卷 / 01期

关键词：

CORONARY-HEART-DISEASE; SMOOTH-MUSCLE-CELLS; CARDIAC-HYPERTROPHY; BLOOD-PRESSURE; IN-VIVO; EXPRESSION; INHIBITION; RISK; METABOLISM; FAMILY;

D O I：

10.1172/JCI62876

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

100103 [病原生物学]; 100218 [急诊医学];

摘要：

The management of cardiovascular risk through lifestyle modification and pharmacotherapy is paramount to the prevention of cardiovascular disease. Epidemiological studies have identified obesity, dyslipidemia, diabetes, and hypertension as interrelated factors that negatively affect cardiovascular health. Recently, genetic and pharmacological evidence in model systems has implicated microRNAs as dynamic modifiers of disease pathogenesis. An expanded understanding of the function of microRNAs in gene regulatory networks associated with cardiovascular risk will enable identification of novel genetic mechanisms of disease and inform the development of innovative therapeutic strategies.

引用

页码：11 / 18

页数：8

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