Fabrication of porous magnetic nanocomposites for bone tissue engineering

被引：12

作者：

Bhowmick, Arundhati ^{[1
]}

Pramanik, Nilkamal ^{[1
]}

Mitra, Tapas ^{[1
]}

Gnanamani, Arumugam ^{[2
]}

Dasc, Manas ^{[3
]}

Kundu, Patit Paban ^{[1
,4
]}

机构：

[1] Univ Calcutta, Dept Polymer Sci & Technol, 92 APC Rd, Kolkata 700009, India

[2] CSIR Cent Leather Res Inst, Div Microbiol, Madras 600020, Tamil Nadu, India

[3] Univ Calcutta, Dept Chem Engn, 92 APC Rd, Kolkata 700009, India

[4] Indian Inst Technol, Dept Chem Engn, Roorkee 247667, Uttar Pradesh, India

来源：

NEW JOURNAL OF CHEMISTRY | 2017年 / 41卷 / 01期

关键词：

COMPOSITE SCAFFOLDS; IN-VITRO; NANOFIBROUS SCAFFOLDS; FIELD; NANOPARTICLES; CALCIUM; BLENDS; HYPERTHERMIA; HYDROGELS; DESIGN;

D O I：

10.1039/c6nj03358j

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

Here, the fabrication and characterization of porous magnetic nanocomposites was carried out via the blending of chitosan, polyethylene glycol and nano-hydroxyapatite-Fe3O4. Scanning electron microscope images revealed a highly interconnected macro-and micro-porous structure. These nanocomposites showed good water uptake abilities and have good antimicrobial properties. The tensile strengths of these nanocomposites were enhanced significantly compared to previously reported results, after the addition of nano-Fe3O4. Moreover, these nanocomposites could be applied for magnetic therapy as this material exhibited superparamagnetic properties. Finally, these nanocomposites were good supports for human osteoblast-like MG-63 cells' growth, attachment and proliferation and they showed good cytocompatibility. No negative effect on the MG-63 cells was observed, suggesting that these nanocomposites have great potential to be applied for bone regeneration.

引用

页码：190 / 197

页数：8

共 71 条

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Enhanced antibacterial activity of iron oxide magnetic nanoparticles treated with Argemone mexicana L. leaf extract: An in vitro study [J].