Long non-coding RNAs: new players in cell differentiation and development

被引：2519

作者：

Fatica, Alessandro ^{[1
]}

Bozzoni, Irene ^{[1
,2
,3
,4
]}

机构：

[1] Sapienza Univ Rome, Dept Biol & Biotechnol Charles Darwin, I-00185 Rome, Italy

[2] CNR, Inst Mol Biol & Pathol, I-00185 Rome, Italy

[3] Ist Pasteur Fdn Cenci Bolognetti, I-00185 Rome, Italy

[4] Sapienza Univ Rome, Ist Italiano Tecnol, Ctr Life Nano Sci Sapienza, I-00161 Rome, Italy

来源：

NATURE REVIEWS GENETICS | 2014年 / 15卷 / 01期

关键词：

X-CHROMOSOME; ANTISENSE TRANSCRIPTION; MUSCLE DIFFERENTIATION; GENE-EXPRESSION; SERIAL ANALYSIS; XIST RNA; IN-VIVO; CHROMATIN; PLURIPOTENCY; INACTIVATION;

D O I：

10.1038/nrg3606

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Genomes of multicellular organisms are characterized by the pervasive expression of different types of non-coding RNAs (ncRNAs). Long ncRNAs (lncRNAs) belong to a novel heterogeneous class of ncRNAs that includes thousands of different species. lncRNAs have crucial roles in gene expression control during both developmental and differentiation processes, and the number of lncRNA species increases in genomes of developmentally complex organisms, which highlights the importance of RNA-based levels of control in the evolution of multicellular organisms. In this Review, we describe the function of lncRNAs in developmental processes, such as in dosage compensation, genomic imprinting, cell differentiation and organogenesis, with a particular emphasis on mammalian development.

引用

页码：7 / 21

页数：15

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