Uncovering a novel mechanism whereby NK cells interfere with glioblastoma virotherapy

被引：18

作者：

Alvarez-Breckenridge, Christopher A. ^{[1
,2
]}

Yu, Jianhua ^{[3
]}

Caligiuri, Michael A. ^{[3
]}

Chiocca, E. Antonio ^{[2
,3
,4
]}

机构：

[1] Ohio State Univ, Med Ctr, Med Scientist Training Program, Columbus, OH 43210 USA

[2] Ohio State Univ, Med Ctr, Dept Neurol Surg, Dardinger Lab Neurooncol & Neurosci, Columbus, OH 43210 USA

[3] Ohio State Univ, Med Ctr, Ctr Comprehens Canc, Columbus, OH 43210 USA

[4] Harvard Univ, Brigham & Womens Hosp, Dept Neurosurg, Dana Farber Canc Inst,Med Sch, Boston, MA 02115 USA

来源：

ONCOIMMUNOLOGY | 2013年 / 2卷 / 04期

关键词：

brain tumor; cancer; glioblastoma; innate immunity; oncolytic virus; VESICULAR STOMATITIS-VIRUS; GLIOMA VIROTHERAPY; SUPPRESSION; RESPONSES; INNATE; POTENCY;

D O I：

10.4161/onci.23658

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Despite initial promising results, the success of clinical trials testing oncolytic viruses in glioblastoma patients has been limited. Innate immunity appears to be one among several barriers against successful viral oncolysis. Recent findings suggest a mechanism by which natural killer cells limit the efficacy of oncolytic viruses via natural cytotoxicity receptors.

引用

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